Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP2 | Q13822 | 1/20 | 0.38 |
| ▸ | ESR1 | P03372 | 1/20 | 0.36 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.36 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.33 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.33 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 3/20 | 0.32 |
| ▸ | ACP1 | P24666 | 1/20 | 0.32 |
| ▸ | CNR1 | P21554 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | BCHE | P06276 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL692774 | 0.80 | NR3C1 (0.44) | ENPP2TP53NPC1RAB9ANR3C1 | |
| SCHEMBL692966 | 0.78 | NR3C1 (0.56) | TP53NPC1USP2RAB9ASMN1; SMN2 | |
| SCHEMBL692379 | 0.76 | PRMT6 (0.43) | ENPP2TP53SMN1; SMN2NR3C1TSHR | |
| SCHEMBL1369219 | 0.75 | ENPP2 (0.42) | ENPP2ESR1ESR2TP53NPC1 | |
| SCHEMBL692541 | 0.75 | NPC1 (0.53) | TP53NPC1USP2RAB9ASMN1; SMN2 | |
| SCHEMBL692595 | 0.72 | TP53 (0.45) | TP53NPC1RAB9AMAPT | |
| SCHEMBL3242528 | 0.69 | ENPP2 (0.45) | ENPP2ESR1ESR2TP53NPC1 | |
| SCHEMBL1369562 | 0.68 | TP53 (0.40) | ENPP2TP53SMN1; SMN2MAPT | |
| SCHEMBL1367936 | 0.63 | TSHR (0.51) | ENPP2TP53SMN1; SMN2NR1H2NR1H3 | |
| SCHEMBL21326414 | 0.63 | ALDH1A1 (0.36) | RAB9ATSHRMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011133600-A1 | COMPOUNDS, COMPOSITIONS AND METHODS COMPRISING PYRIDAZINE SULFONAMIDE DERIVATIVES | INSTITUTE FOR ONEWORLD HEALTH (US) | 2011-10-27 | — | — | WO | disclosed |
| WO-2010123822-A1 | COMPOUNDS, COMPOSITIONS AND METHODS COMPRISING PYRIDAZINE SULFONAMIDE DERIVATIVES | INSTITUTE FOR ONEWORLD HEALTH (US) | 2010-10-28 | — | — | WO | disclosed |