Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 7/20 | 0.45 |
| ▸ | LMNA | P02545 | 4/20 | 0.45 |
| ▸ | THRB | P10828 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 7/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | PGR | P06401 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HTR6 | P50406 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL692541 | 0.87 | NPC1 (0.53) | TP53LMNATHRBMAPTPOLB | |
| SCHEMBL692966 | 0.85 | NR3C1 (0.56) | TP53LMNATHRBPOLBALDH1A1 | |
| SCHEMBL692379 | 0.83 | PRMT6 (0.43) | TP53LMNATHRBMAPTPOLB | |
| SCHEMBL692774 | 0.81 | NR3C1 (0.44) | TP53LMNATHRBMAPTPOLB | |
| SCHEMBL1369219 | 0.72 | ENPP2 (0.42) | TP53LMNAMAPTALDH1A1HPGD | |
| SCHEMBL7710033 | 0.72 | ENPP2 (0.38) | TP53MAPTNPC1RAB9A | |
| SCHEMBL30565215 | 0.69 | PGR (0.75) | MAPTPOLBALDH1A1HTTPGR | |
| SCHEMBL1403074 | 0.69 | PGR (0.75) | MAPTPOLBALDH1A1HTTPGR | |
| SCHEMBL28106677 | 0.68 | NR3C1 (0.49) | ALDH1A1PGRHTR6BRD4HSD17B2 | |
| SCHEMBL14433749 | 0.68 | HSD17B2 (0.66) | POLBPGRHTR6BRD4HSD17B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103068390-A | Compounds, compositions, and methods comprising pyridazine sulfonamide derivatives | INST ONEWORLD HEALTH | 2013-04-24 | — | — | CN | claimed |
| EP-2560654-A1 | COMPOUNDS, COMPOSITIONS AND METHODS COMPRISING PYRIDAZINE SULFONAMIDE DERIVATIVES | Institute for OneWorld Health (US) | 2013-02-27 | — | — | EP | claimed |
| US-20120129858-A1 | COMPOUNDS, COMPOSITIONS AND METHODS COMPRISING PYRIDAZINE SULFONAMIDE DERIVATIVES | INSTITUTE FOR ONEWORLD HEALTH | 2012-05-24 | — | — | US | claimed |
| CN-102458122-A | Compounds, compositions and methods comprising pyridazine sulfonamide derivatives | INST ONEWORLD HEALTH | 2012-05-16 | — | — | CN | claimed |
| EP-2421368-A1 | COMPOUNDS, COMPOSITIONS AND METHODS COMPRISING PYRIDAZINE SULFONAMIDE DERIVATIVES | Institute for OneWorld Health (US) | 2012-02-29 | — | — | EP | claimed |
| US-20110288093-A1 | Compounds, Compositions, and Methods Comprising Pyridazine Sulfonamide Derivatives | INSTITUTE FOR ONEWORLD HEALTH | 2011-11-24 | — | — | US | claimed |
| WO-2011133600-A1 | COMPOUNDS, COMPOSITIONS AND METHODS COMPRISING PYRIDAZINE SULFONAMIDE DERIVATIVES | INSTITUTE FOR ONEWORLD HEALTH (US) | 2011-10-27 | — | — | WO | claimed |
| WO-2010123822-A1 | COMPOUNDS, COMPOSITIONS AND METHODS COMPRISING PYRIDAZINE SULFONAMIDE DERIVATIVES | INSTITUTE FOR ONEWORLD HEALTH (US) | 2010-10-28 | — | — | WO | claimed |
| CN-103068390-A | Compounds, compositions, and methods comprising pyridazine sulfonamide derivatives | INST ONEWORLD HEALTH | 2013-04-24 | — | — | CN | disclosed |
| EP-2560654-A1 | COMPOUNDS, COMPOSITIONS AND METHODS COMPRISING PYRIDAZINE SULFONAMIDE DERIVATIVES | Institute for OneWorld Health (US) | 2013-02-27 | — | — | EP | disclosed |
| US-20120129858-A1 | COMPOUNDS, COMPOSITIONS AND METHODS COMPRISING PYRIDAZINE SULFONAMIDE DERIVATIVES | INSTITUTE FOR ONEWORLD HEALTH | 2012-05-24 | — | — | US | disclosed |
| US-20120129858-A1 | COMPOUNDS, COMPOSITIONS AND METHODS COMPRISING PYRIDAZINE SULFONAMIDE DERIVATIVES | INSTITUTE FOR ONEWORLD HEALTH | 2012-05-24 | — | — | US | disclosed |
| US-20120129858-A1 | COMPOUNDS, COMPOSITIONS AND METHODS COMPRISING PYRIDAZINE SULFONAMIDE DERIVATIVES | INSTITUTE FOR ONEWORLD HEALTH | 2012-05-24 | — | — | US | disclosed |
| CN-102458122-A | Compounds, compositions and methods comprising pyridazine sulfonamide derivatives | INST ONEWORLD HEALTH | 2012-05-16 | — | — | CN | disclosed |
| EP-2421368-A1 | COMPOUNDS, COMPOSITIONS AND METHODS COMPRISING PYRIDAZINE SULFONAMIDE DERIVATIVES | Institute for OneWorld Health (US) | 2012-02-29 | — | — | EP | disclosed |
| US-20110288093-A1 | Compounds, Compositions, and Methods Comprising Pyridazine Sulfonamide Derivatives | INSTITUTE FOR ONEWORLD HEALTH | 2011-11-24 | — | — | US | disclosed |
| US-20110288093-A1 | Compounds, Compositions, and Methods Comprising Pyridazine Sulfonamide Derivatives | INSTITUTE FOR ONEWORLD HEALTH | 2011-11-24 | — | — | US | disclosed |
| US-20110288093-A1 | Compounds, Compositions, and Methods Comprising Pyridazine Sulfonamide Derivatives | INSTITUTE FOR ONEWORLD HEALTH | 2011-11-24 | — | — | US | disclosed |
| WO-2011133600-A1 | COMPOUNDS, COMPOSITIONS AND METHODS COMPRISING PYRIDAZINE SULFONAMIDE DERIVATIVES | INSTITUTE FOR ONEWORLD HEALTH (US) | 2011-10-27 | — | — | WO | disclosed |
| WO-2010123822-A1 | COMPOUNDS, COMPOSITIONS AND METHODS COMPRISING PYRIDAZINE SULFONAMIDE DERIVATIVES | INSTITUTE FOR ONEWORLD HEALTH (US) | 2010-10-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120129858-A1 | COMPOUNDS, COMPOSITIONS AND METHODS COMPRISING PYRIDAZINE SULFONAMIDE DERIVATIVES | CFTR, PKD1, PKD2 | TP53 1160/4885LMNA 3450/4885THRB 2860/4885 |
| US-20110288093-A1 | Compounds, Compositions, and Methods Comprising Pyridazine Sulfonamide Derivatives | SCN1A, CLIC1, CLCN2 | TP53 3179/4885LMNA 762/4885THRB 3099/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.