Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 8/20 | 0.38 |
| ▸ | PPARA | Q07869 | 5/20 | 0.38 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.34 |
| ▸ | HAT1 | O14929 | 4/20 | 0.32 |
| ▸ | EP300 | Q09472 | 4/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | CHEK2 | O96017 | 4/20 | 0.32 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.32 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7707708 | 0.77 | KMT2A (0.41) | PPARGPPARAMEN1KMT2AATM | |
| SCHEMBL7424222 | 0.74 | HSD17B10 (0.43) | MEN1KMT2AATML3MBTL1CHEK2 | |
| SCHEMBL8555053 | 0.69 | PPARG (0.32) | PPARGPPARAMEN1KMT2AATM | |
| SCHEMBL7422734 | 0.69 | KDM4E (0.44) | PPARGMEN1KMT2AATML3MBTL1 | |
| Hydrochloric Acid SCHEMBL8627726 | 0.67 | ALOX5 (0.40) | HAT1EP300ALOX5 | |
| SCHEMBL7710516 | 0.67 | PDPK1 (0.40) | PPARGHAT1EP300MEN1KMT2A | |
| SCHEMBL8554263 | 0.67 | ALOX5 (0.39) | PLA2G2AHAT1EP300MEN1KMT2A | |
| SCHEMBL8556642 | 0.65 | PPARG (0.42) | PPARGMEN1KMT2AATML3MBTL1 | |
| SCHEMBL7416246 | 0.65 | ALOX5 (0.44) | MEN1KMT2AATML3MBTL1ALOX5 | |
| SCHEMBL8556645 | 0.65 | PARP1 (0.52) | MEN1KMT2AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6358992-B1 | Method of inhibiting neoplastic cells with indole derivatives | CELL PATHWAYS, INC. | 2002-03-19 | — | — | US | disclosed |