Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 6/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6930961 | 0.85 | ALOX5 (0.39) | KMT2AMEN1ATML3MBTL1ALDH1A1 | |
| SCHEMBL7710517 | 0.77 | PPARG (0.38) | KMT2AMEN1ATML3MBTL1PPARG | |
| SCHEMBL7707705 | 0.76 | SMN1; SMN2 (0.42) | KMT2AMEN1ATML3MBTL1ALDH1A1 | |
| SCHEMBL8556176 | 0.74 | MEN1 (0.42) | KMT2AMEN1ATML3MBTL1ALDH1A1 | |
| SCHEMBL8554263 | 0.74 | ALOX5 (0.39) | KMT2AMEN1ATML3MBTL1ALDH1A1 | |
| SCHEMBL8558633 | 0.73 | ALOX5 (0.40) | ALDH1A1LMNAMAPTPDE3BPDE3A | |
| SCHEMBL8551585 | 0.73 | SMN1; SMN2 (0.48) | KMT2AMEN1ATML3MBTL1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL8627726 | 0.73 | ALOX5 (0.40) | ALDH1A1LMNAMAPTPDE3BPDE3A | |
| SCHEMBL7422800 | 0.72 | KMT2A (0.58) | KMT2AMEN1ATML3MBTL1ALDH1A1 | |
| SCHEMBL8555588 | 0.72 | SMN1; SMN2 (0.47) | KMT2AMEN1ATML3MBTL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6358992-B1 | Method of inhibiting neoplastic cells with indole derivatives | CELL PATHWAYS, INC. | 2002-03-19 | — | — | US | disclosed |
| US-6069156-A | Indole derivatives as cGMP-PDE inhibitors | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2000-05-30 | — | — | US | disclosed |