Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.63 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.63 |
| ▸ | TSHR | P16473 | 1/20 | 0.61 |
| ▸ | ABL1 | P00519 | 5/20 | 0.51 |
| ▸ | BCR | P11274 | 5/20 | 0.51 |
| ▸ | PIK3CA | P42336 | 7/20 | 0.49 |
| ▸ | PIK3R1 | P27986 | 4/20 | 0.49 |
| ▸ | MTOR | P42345 | 3/20 | 0.49 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.45 |
| ▸ | NOS1 | P29475 | 1/20 | 0.45 |
| ▸ | DHFR | P00374 | 1/20 | 0.45 |
| ▸ | RICTOR | Q6R327 | 1/20 | 0.45 |
| ▸ | RPTOR | Q8N122 | 1/20 | 0.45 |
| ▸ | MAPKAP1 | Q9BPZ7 | 1/20 | 0.45 |
| ▸ | MLST8 | Q9BVC4 | 1/20 | 0.45 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14541937 | 0.80 | KDM4E (0.69) | ALDH1A1TSHRPIK3CAPIK3R1MTOR | |
| SCHEMBL23019331 | 0.80 | PIK3CA (0.49) | PIK3CAPIK3R1MTORPIK3CBKDM4E | |
| SCHEMBL3344468 | 0.80 | ALDH1A1 (0.63) | ALDH1A1MAPK1TSHRABL1BCR | |
| SCHEMBL18072393 | 0.80 | PIK3CA (0.54) | PIK3CAPIK3R1MTORPIK3CBKDM4E | |
| SCHEMBL7712374 | 0.78 | PIK3CA (0.48) | MAPK1PIK3CAPIK3R1MTORPIK3CB | |
| SCHEMBL25598894 | 0.76 | IKBKB (0.56) | ALDH1A1MAPK1TSHRPIK3CAPIK3R1 | |
| SCHEMBL20446033 | 0.75 | ABL1 (0.46) | ALDH1A1MAPK1ABL1BCRHRH4 | |
| SCHEMBL1445139 | 0.75 | KDM4E (0.51) | ALDH1A1MAPK1TSHRPIK3CAPIK3R1 | |
| SCHEMBL30366458 | 0.75 | KDM4E (0.51) | ALDH1A1MAPK1TSHRPIK3CAPIK3R1 | |
| SCHEMBL7708544 | 0.74 | NOS1 (0.58) | PIK3CAPIK3R1MTORKDM4ENOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5098902-A | Administering 5-bromo-4- 4-morpholinyl!-2-pyridinamine or 4- 4-morpholinyl-2- 1-piperazinyl!thieno 3,2-d!pyrimidine for cognitive activators | WARNER-LAMBERT COMPANY (US) | 1992-03-24 | — | — | US | claimed |
| US-5075305-A | For enhancing nerve growth factor | WARNER-LAMBERT COMPANY (US) | 1991-12-24 | — | — | US | claimed |
| US-6440965-B1 | Substituted pyrimidine derivatives, their preparation and their use in the treatment of neurodegenerative or neurological disorders of the central nervous system | KRENITSKY PHARMACEUTICALS, INC. | 2002-08-27 | — | — | US | disclosed |
| US-5098902-A | Administering 5-bromo-4- 4-morpholinyl!-2-pyridinamine or 4- 4-morpholinyl-2- 1-piperazinyl!thieno 3,2-d!pyrimidine for cognitive activators | WARNER-LAMBERT COMPANY (US) | 1992-03-24 | — | — | US | disclosed |
| US-5098902-A | Administering 5-bromo-4- 4-morpholinyl!-2-pyridinamine or 4- 4-morpholinyl-2- 1-piperazinyl!thieno 3,2-d!pyrimidine for cognitive activators | WARNER-LAMBERT COMPANY (US) | 1992-03-24 | — | — | US | disclosed |
| US-5075305-A | For enhancing nerve growth factor | WARNER-LAMBERT COMPANY (US) | 1991-12-24 | — | — | US | disclosed |
| US-5075305-A | For enhancing nerve growth factor | WARNER-LAMBERT COMPANY (US) | 1991-12-24 | — | — | US | disclosed |