Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 16/20 | 0.38 |
| ▸ | CTSD | P07339 | 5/20 | 0.38 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.33 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.33 |
| ▸ | BACE2 | Q9Y5Z0 | 2/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.32 |
| ▸ | GSK3B | P49841 | 1/20 | 0.31 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.31 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7715226 | 0.76 | BACE1 (0.37) | BACE1CTSDBACE2GSK3B | |
| SCHEMBL7705409 | 0.75 | BACE1 (0.45) | BACE1CTSDBACE2KCNH2GSK3B | |
| SCHEMBL7705408 | 0.72 | BACE1 (0.35) | BACE1CTSDKCNH2 | |
| SCHEMBL7705399 | 0.68 | BACE1 (0.35) | BACE1CTSDBACE2SCN9A | |
| SCHEMBL2573986 | 0.65 | BACE1 (0.64) | BACE1CTSDBACE2 | |
| SCHEMBL7712995 | 0.61 | BACE1 (0.41) | BACE1CTSDBACE2KCNH2 | |
| SCHEMBL7710882 | 0.58 | CCNC (0.38) | BACE1CTSD | |
| SCHEMBL2371171 | 0.58 | BACE1 (0.63) | BACE1CTSDBACE2KCNH2 | |
| SCHEMBL7704729 | 0.58 | MKNK1 (0.39) | BACE1PRMT5WDR77KCNH2 | |
| SCHEMBL7715200 | 0.58 | MKNK1 (0.37) | BACE1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011130741-A1 | COMPOUNDS FOR TREATING NEURODEGENERATIVE DISEASES | ARRAY BIOPHARMA INC. (US) | 2011-10-20 | — | — | WO | disclosed |