Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 6/20 | 0.48 |
| ▸ | DPP7 | Q9UHL4 | 6/20 | 0.48 |
| ▸ | OPRL1 | P41146 | 6/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 5/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 5/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 5/20 | 0.38 |
| ▸ | CACNA2D1 | P54289 | 4/20 | 0.37 |
| ▸ | CACNA1B | Q00975 | 4/20 | 0.37 |
| ▸ | CACNB1 | Q02641 | 4/20 | 0.37 |
| ▸ | CACNA1C | Q13936 | 3/20 | 0.37 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.37 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.36 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL7718434 | 0.92 | DPP4 (0.40) | DPP4DPP7OPRL1OPRM1OPRD1 | |
| SCHEMBL7713231 | 0.82 | DPP4 (0.41) | DPP4DPP7OPRL1OPRM1OPRD1 | |
| SCHEMBL7715202 | 0.74 | MGLL (0.38) | DPP4DPP7OPRL1OPRM1OPRD1 | |
| SCHEMBL7714833 | 0.73 | KDM4D (0.43) | — | |
| SCHEMBL7714834 | 0.73 | KDM4D (0.43) | — | |
| SCHEMBL4463788 | 0.72 | DPP4 (0.46) | DPP4OPRL1OPRM1OPRD1OPRK1 | |
| SCHEMBL10331845 | 0.65 | ACE (0.52) | DPP4 | |
| Resorcinol SCHEMBL11567030 | 0.62 | ALDH1A1 (0.57) | — | |
| SCHEMBL1527310 | 0.62 | ALDH1A1 (0.51) | DPP4 | |
| SCHEMBL1527357 | 0.62 | ALDH1A1 (0.51) | DPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6441017-B1 | Inhibitors of prenyl-protein transferase | MERCK & CO., INC. | 2002-08-27 | — | — | US | disclosed |
| EP-1214326-A1 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 2002-06-19 | — | — | EP | disclosed |
| WO-2001018006-A1 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 2001-03-15 | — | — | WO | disclosed |