Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 1/20 | 0.41 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.41 |
| ▸ | OPRL1 | P41146 | 6/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 5/20 | 0.37 |
| ▸ | OPRD1 | P41143 | 5/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 5/20 | 0.37 |
| ▸ | CACNA2D1 | P54289 | 3/20 | 0.34 |
| ▸ | CACNA1B | Q00975 | 3/20 | 0.34 |
| ▸ | CACNB1 | Q02641 | 3/20 | 0.34 |
| ▸ | CACNA1C | Q13936 | 3/20 | 0.34 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.34 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.34 |
| ▸ | MGLL | Q99685 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7715202 | 0.91 | MGLL (0.38) | DPP4DPP7OPRL1OPRM1OPRD1 | |
| Trifluoroacetic Acid SCHEMBL7713229 | 0.82 | DPP4 (0.48) | DPP4DPP7OPRL1OPRM1OPRD1 | |
| Trifluoroacetic Acid SCHEMBL7718434 | 0.73 | DPP4 (0.40) | DPP4DPP7OPRL1OPRM1OPRD1 | |
| SCHEMBL7714834 | 0.64 | KDM4D (0.43) | — | |
| SCHEMBL7714833 | 0.64 | KDM4D (0.43) | — | |
| SCHEMBL24901075 | 0.60 | BCHE (0.43) | TRPA1 | |
| SCHEMBL19471892 | 0.60 | HDAC1 (0.49) | — | |
| SCHEMBL14275595 | 0.60 | HDAC1 (0.49) | — | |
| SCHEMBL17784780 | 0.60 | HDAC1 (0.49) | — | |
| SCHEMBL10180800 | 0.59 | ESR1 (0.49) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6441017-B1 | Inhibitors of prenyl-protein transferase | MERCK & CO., INC. | 2002-08-27 | — | — | US | disclosed |
| EP-1214326-A1 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 2002-06-19 | — | — | EP | disclosed |
| WO-2001018006-A1 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 2001-03-15 | — | — | WO | disclosed |