SCHEMBL2235378

SCHEMBL2235378

CCN(CC)C[N]c1ccccn1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NOS3 P29474 2/20 0.42
NOS1 P29475 2/20 0.42
NOS2 P35228 2/20 0.42
ADRA2A P08913 3/20 0.40
ADRA2B P18089 3/20 0.40
ADRA2C P18825 3/20 0.40
MAOA P21397 2/20 0.40
MAOB P27338 2/20 0.40
PLAU P00749 1/20 0.40
ALDH1A1 P00352 1/20 0.37
KCNA5 P22460 2/20 0.37
CYP2D6 P10635 1/20 0.37
KCNE1 P15382 1/20 0.37
MAPT P10636 1/20 0.36
SMN1; SMN2 Q16637 1/20 0.36
LIN28A Q9H9Z2 1/20 0.36
TDP1 Q9NUW8 1/20 0.36
CHRM2 P08172 1/20 0.35
CHRM4 P08173 1/20 0.35
CHRM5 P08912 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1850336 0.81 MAOA (0.46) NOS3NOS1NOS2ADRA2AADRA2B
SCHEMBL1629938 0.78
SCHEMBL7713660 0.75 NOS3 (0.46) NOS3NOS1NOS2ADRA2AADRA2B
SCHEMBL6603664 0.72 NOS3 (0.44) NOS3NOS1NOS2ADRA2AADRA2B
SCHEMBL1849181 0.69 HRH3 (0.44) NOS3NOS1NOS2ADRA2AADRA2B
SCHEMBL3499052 0.69 MAOA (0.50) NOS3NOS1NOS2ADRA2AADRA2B
SCHEMBL3499053 0.69 MAOA (0.50) NOS3NOS1NOS2ADRA2AADRA2B
SCHEMBL1850348 0.67 ADRA2A (0.48) NOS3NOS1NOS2ADRA2AADRA2B
SCHEMBL804309 0.67 TDP1 (0.70) ALDH1A1KCNA5CYP2D6KCNE1MAPT
SCHEMBL8604224 0.67 TDP1 (0.70) ALDH1A1KCNA5CYP2D6KCNE1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2528920-A2 BICYCLIC HETEROARYL DERIVATIVES HAVING INHIBITORY ACTIVITY FOR PROTEIN KINASE Hanmi Pharm. Co., Ltd. (KR) 2012-12-05 EP claimed
WO-2011093672-A2 BICYCLIC HETEROARYL DERIVATIVES HAVING INHIBITORY ACTIVITY FOR PROTEIN KINASE HANMI PHARM. CO., LTD. (KR) 2011-08-04 WO claimed
EP-2528920-A2 BICYCLIC HETEROARYL DERIVATIVES HAVING INHIBITORY ACTIVITY FOR PROTEIN KINASE Hanmi Pharm. Co., Ltd. (KR) 2012-12-05 EP disclosed
WO-2011093672-A2 BICYCLIC HETEROARYL DERIVATIVES HAVING INHIBITORY ACTIVITY FOR PROTEIN KINASE HANMI PHARM. CO., LTD. (KR) 2011-08-04 WO disclosed