Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 1/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | AGER | Q15109 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | MYC | P01106 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | NAPRT | Q6XQN6 | 2/20 | 0.41 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.41 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9507731 | 0.96 | P2RX7 (0.58) | P2RX7KDM4ETDP1ALDH1A1L3MBTL1 | |
| SCHEMBL9506617 | 0.82 | SIRT3 (0.49) | P2RX7KDM4ETDP1ALDH1A1L3MBTL1 | |
| SCHEMBL11078263 | 0.81 | P2RX7 (0.63) | P2RX7KDM4ETDP1ALDH1A1L3MBTL1 | |
| SCHEMBL12230958 | 0.79 | P2RX7 (0.61) | P2RX7KDM4ETDP1ALDH1A1L3MBTL1 | |
| SCHEMBL71547 | 0.79 | KDM4E (0.63) | P2RX7KDM4ETDP1ALDH1A1L3MBTL1 | |
| SCHEMBL29496114 | 0.79 | P2RX7 (0.61) | P2RX7KDM4ETDP1ALDH1A1L3MBTL1 | |
| SCHEMBL70978 | 0.79 | P2RX7 (0.61) | P2RX7KDM4ETDP1ALDH1A1L3MBTL1 | |
| SCHEMBL29651292 | 0.79 | KDM4E (0.63) | P2RX7KDM4ETDP1ALDH1A1L3MBTL1 | |
| Quinolinic Acid SCHEMBL5674127 | 0.78 | KDM4E (0.53) | P2RX7KDM4ETDP1ALDH1A1L3MBTL1 | |
| SCHEMBL724087 | 0.78 | P2RX7 (0.65) | P2RX7KDM4ETDP1ALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6376548-B1 | FUNGICIDES; HERBICIDES; INSECTICIDES | ROHM AND HAAS COMPANY | 2002-04-23 | — | — | US | disclosed |
| WO-2001056358-A2 | ENHANCED PROPERTIED PESTICIDES | ROHM AND HAAS COMPANY (US) | 2001-08-09 | — | — | WO | disclosed |
| US-5908841-A | 5,11-dihydro-6H-dipyrido 3,2-b:2',3'-e!azepine-6-ones and their use in the prevention of treatment of HIV infection | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 1999-06-01 | — | — | US | disclosed |
| WO-1999007380-A1 | 5,11-DIHYDRO-6H-DIPYRIDO[3,2-b:2',3'-e] AZEPIN-6-ONES AND THEIR USE IN THE PREVENTION OR TREATMENT OF HIV INFECTION | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 1999-02-18 | — | — | WO | disclosed |