SCHEMBL771687

SCHEMBL771687

COC(=O)c1ccc(Cl)cc1N

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ABL1 P00519 1/20 1.00
KDM4E B2RXH2 10/20 0.66
ALDH1A1 P00352 9/20 0.66
GAA P10253 5/20 0.66
HSD17B10 Q99714 3/20 0.66
MAPT P10636 3/20 0.66
HPGD P15428 3/20 0.66
GLA P06280 2/20 0.66
CASP1 P29466 1/20 0.66
CASP7 P55210 1/20 0.66
ATM Q13315 1/20 0.66
CFTR P13569 2/20 0.58
NR4A2 P43354 2/20 0.51
RAB9A P51151 3/20 0.51
PKM P14618 1/20 0.51
FLT1 P17948 1/20 0.50
FLT4 P35916 1/20 0.50
KDR P35968 1/20 0.50
LMNA P02545 1/20 0.50
RXFP1 Q9HBX9 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL267531 0.85 ABL1 (0.74) ABL1KDM4EALDH1A1GAAHSD17B10
SCHEMBL21857090 0.83 ABL1 (0.70) ABL1KDM4EALDH1A1GAAHSD17B10
SCHEMBL6100118 0.82 ABL1 (0.70) ABL1KDM4EALDH1A1GAAHSD17B10
SCHEMBL8205593 0.82 ABL1 (0.70) ABL1KDM4EALDH1A1GAAHSD17B10
SCHEMBL608814 0.81 ABL1 (0.68) ABL1KDM4EALDH1A1MAPTHPGD
SCHEMBL29400478 0.81 GAA (0.70) ABL1KDM4EALDH1A1GAAHSD17B10
SCHEMBL2926607 0.81 GAA (0.70) ABL1KDM4EALDH1A1GAAHSD17B10
SCHEMBL1189663 0.81 ABL1 (0.68) ABL1KDM4EALDH1A1GAAHSD17B10
SCHEMBL1186026 0.81 ABL1 (0.68) ABL1KDM4EALDH1A1GAAHSD17B10
SCHEMBL11177948 0.80 ABL1 (0.65) ABL1KDM4EALDH1A1GAAHSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 654 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114507192-A Preparation method of intermediate for preparing tianeptine sodium 上海微巨实业有限公司 2022-05-17 CN claimed
US-4288362-A Monoazo pigments containing a quinazo linonylacetoacetanilide coupling component BAYER AKTIENGESELLSCHAFT (DE) 1981-09-08 US claimed
EP-4734979-A2 TMEM175 AGONISTS, COMPOSITIONS, AND METHODS OF USE Caraway Therapeutics, Inc. (US) 2026-05-06 EP disclosed
US-20260070932-A1 INHIBITORS OF COMPLEMENT FACTORS AND USES THEREOF ANNEXON INC (US) 2026-03-12 US disclosed
US-12509474-B2 Inhibitors of complement factors and uses thereof ANNEXON, INC. (US) 2025-12-30 US disclosed
EP-4582423-A1 NOVEL TRICYCLIC DERIVATIVE COMPOUND AND USES THEREOF Hanmi Pharm. Co., Ltd. (KR) 2025-07-09 EP disclosed
US-20250206724-A1 SUBSTITUTED 3-AMINO INDAZOLE DERIVATIVES AS KINASE INHIBITORS NERVIANO MEDICAL SCIENCES S.R.L. (IT) 2025-06-26 US disclosed
WO-2025128938-A1 BENZOTHIAZOLE DERIVATIVES USEFUL AS RXFP1 RECEPTOR AGONISTS ELI LILLY AND COMPANY (US) 2025-06-19 WO disclosed
US-20250197413-A1 RXFP1 RECEPTOR AGONISTS ELI LILLY AND COMPANY 2025-06-19 US disclosed
CN-120077041-A Tricyclic derivative compounds and use thereof 韩美药品株式会社 2025-05-30 CN disclosed
CN-119143671-B Method for simply and conveniently synthesizing quinolinone derivative through one-pot method of carboinsertion reaction 九洲药业(杭州)有限公司 2025-05-16 CN disclosed
US-4225489-A Heterocyclic azo dyes and pigments containing 4-quinazolinone moieties BAYER AKTIENGESELLSCHAFT (DE) 1980-09-30 US disclosed
US-4198350-A Amination/demethylation process STANDARD OIL COMPANY (INDIANA) (US) 1980-04-15 US disclosed
US-4163059-A Pesticidally active 4,5-dichloro-3-substituted-phenylimino-1,2-dithiolenes BAYER AKTIENGESELLSCHAFT (DE) 1979-07-31 US disclosed
US-4150019-A COLORFAST, HEAT RESISTANT, MIGRATION HOECHST AKTIENGESELLSCHAFT (DE) 1979-04-17 US disclosed
US-4083842-A USEFUL AS PIGMENTS FOR SYNTHETIC POLYMERS SANDOZ LTD. (CH) 1978-04-11 US disclosed
US-4014863-A LACQUERS, PRINTING INKS, PAINTS BAYER AKTIENGESELLSCHAFT (DT) 1977-03-29 US disclosed
US-4000275-A BENZIMIDAZO(2,1-B) QUINAZOLIN-12(6H)ONES ELI LILLY AND COMPANY (US) 1976-12-28 US disclosed
US-3989689-A ANTIINFLAMMATORY CIBA-GEIGY CORPORATION (US) 1976-11-02 US disclosed
US-3949081-A 4-Carbamoyl-1-benzazepines as antiinflammatory agents CIBA-GEIGY CORPORATION (US) 1976-04-06 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250197413-A1 RXFP1 RECEPTOR AGONISTS RXFP1, RXFP3, RXFP2 ABL1 1785/4885KDM4E 3828/4885ALDH1A1 1973/4885
US-20250206724-A1 SUBSTITUTED 3-AMINO INDAZOLE DERIVATIVES AS KINASE INHIBITORS CDK1, CDK11A, CDK3 ABL1 333/4885KDM4E 1212/4885ALDH1A1 4385/4885
US-12509474-B2 Inhibitors of complement factors and uses thereof SSB, UACA, CFH ABL1 2003/4885KDM4E 2913/4885ALDH1A1 3178/4885
US-20260070932-A1 INHIBITORS OF COMPLEMENT FACTORS AND USES THEREOF CFH, CFB, C5 ABL1 2557/4885KDM4E 4178/4885ALDH1A1 3094/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.