Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPAR1 | Q92633 | 1/20 | 0.33 |
| ▸ | LPAR5 | Q9H1C0 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.33 |
| ▸ | TMPRSS15 | P98073 | 2/20 | 0.33 |
| ▸ | PYGL | P06737 | 1/20 | 0.32 |
| ▸ | TYMS | P04818 | 4/20 | 0.32 |
| ▸ | CCKBR | P32239 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.31 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.31 |
| ▸ | THRA | P10827 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7717407 | 0.87 | EGFR (0.42) | CA12CA1CA2CA9PRSS1 | |
| SCHEMBL8722086 | 0.81 | CA2 (0.42) | CA12CA1CA2CA9PRSS1 | |
| SCHEMBL8722082 | 0.79 | CA1 (0.42) | CA12CA1CA2CA9PYGL | |
| SCHEMBL8722067 | 0.78 | CA1 (0.47) | CA12CA1CA2CA9CCKBR | |
| SCHEMBL8726467 | 0.77 | CA2 (0.41) | CA12CA1CA2CA9PYGL | |
| SCHEMBL7903773 | 0.76 | PYGL (0.38) | CA12CA1CA2CA9TMPRSS15 | |
| SCHEMBL7902106 | 0.76 | PYGL (0.38) | CA12CA1CA2CA9TMPRSS15 | |
| SCHEMBL8726548 | 0.75 | ALDH1A1 (0.43) | CA12CA1CA2CA9PYGL | |
| SCHEMBL7715738 | 0.75 | CA1 (0.44) | CA12CA1CA2CA9ALDH1A1 | |
| SCHEMBL7711928 | 0.75 | MCL1 (0.43) | LPAR1LPAR5CA1CA2MCL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6436691-B1 | CONJUGATE WHICH IS SUBSTANTIALLY NON-IMMUNOGENIC IN HUMANS COMPRISING TARGETING MOIETY CAPABLE OF BINDING WITH TUMOR ASSOCIATED ANTIGEN LINKED TO MUTATED FORM OF CARBOXYPEPTIDASE B ENZYME CAPABLE OF CONVERTING PRODRUG INTO ANTICANCER DRUG | ZENECA LIMITED (GB) | 2002-08-20 | — | — | US | disclosed |
| WO-1998035982-A1 | COMPOUNDS FOR USE IN ADEPT | ZENECA LIMITED (GB) | 1998-08-20 | — | — | WO | disclosed |
| EP-0844885-A2 | CHEMICAL COMPOUNDS | ZENECA LIMITED (GB) | 1998-06-03 | — | — | EP | disclosed |
| WO-1997007769-A2 | CHEMICAL COMPOUNDS | ZENECA LIMITED (GB) | 1997-03-06 | — | — | WO | disclosed |