Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 3/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | MMP2 | P08253 | 2/20 | 0.37 |
| ▸ | MMP9 | P14780 | 2/20 | 0.37 |
| ▸ | MMP12 | P39900 | 2/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.36 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8722107 | 0.88 | PYGL (0.36) | CA1CA12CA9UTS2RCA2 | |
| SCHEMBL8722146 | 0.88 | CA1 (0.43) | CA1CA12CA9UTS2RCA2 | |
| SCHEMBL7717390 | 0.87 | MAPT (0.36) | CA1CA12CA9UTS2RALDH1A1 | |
| SCHEMBL8722150 | 0.87 | CA2 (0.42) | UTS2RCA2ALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL8722086 | 0.86 | CA2 (0.42) | CA1CA12CA9CA2 | |
| SCHEMBL8726548 | 0.86 | ALDH1A1 (0.43) | CA1CA12CA9UTS2RCA2 | |
| SCHEMBL7715732 | 0.84 | EGFR (0.53) | CA1CA12CA9UTS2RCA2 | |
| SCHEMBL8724202 | 0.83 | EGFR (0.43) | CA1CA12CA9UTS2RCA2 | |
| SCHEMBL7711928 | 0.83 | MCL1 (0.43) | CA1CA2MCL1 | |
| SCHEMBL8726236 | 0.81 | TAS1R3 (0.40) | ALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0844885-A2 | CHEMICAL COMPOUNDS | ZENECA LIMITED (GB) | 1998-06-03 | — | — | EP | claimed |
| WO-1997007769-A2 | CHEMICAL COMPOUNDS | ZENECA LIMITED (GB) | 1997-03-06 | — | — | WO | claimed |
| US-6436691-B1 | CONJUGATE WHICH IS SUBSTANTIALLY NON-IMMUNOGENIC IN HUMANS COMPRISING TARGETING MOIETY CAPABLE OF BINDING WITH TUMOR ASSOCIATED ANTIGEN LINKED TO MUTATED FORM OF CARBOXYPEPTIDASE B ENZYME CAPABLE OF CONVERTING PRODRUG INTO ANTICANCER DRUG | ZENECA LIMITED (GB) | 2002-08-20 | — | — | US | disclosed |
| WO-1998035982-A1 | COMPOUNDS FOR USE IN ADEPT | ZENECA LIMITED (GB) | 1998-08-20 | — | — | WO | disclosed |
| EP-0844885-A2 | CHEMICAL COMPOUNDS | ZENECA LIMITED (GB) | 1998-06-03 | — | — | EP | disclosed |
| WO-1997007769-A2 | CHEMICAL COMPOUNDS | ZENECA LIMITED (GB) | 1997-03-06 | — | — | WO | disclosed |