Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 7/20 | 0.33 |
| ▸ | RXRB | P28702 | 7/20 | 0.33 |
| ▸ | RXRG | P48443 | 4/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.33 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.33 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.31 |
| ▸ | DRD2 | P14416 | 1/20 | 0.31 |
| ▸ | DRD1 | P21728 | 1/20 | 0.31 |
| ▸ | DRD5 | P21918 | 1/20 | 0.31 |
| ▸ | DRD3 | P35462 | 1/20 | 0.31 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.31 |
| ▸ | BACE1 | P56817 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7483555 | 0.93 | CYP2A6 (0.38) | CYP2A6BACE1 | |
| SCHEMBL7487183 | 0.80 | ADRB2 (0.46) | CYP2A6MRGPRX4 | |
| SCHEMBL2061100 | 0.75 | DRD2 (0.47) | DRD2DRD1DRD5DRD3 | |
| SCHEMBL8078287 | 0.75 | DRD2 (0.37) | DRD2DRD3 | |
| SCHEMBL7718293 | 0.74 | — | — | |
| SCHEMBL5153891 | 0.74 | ADRB2 (0.37) | MRGPRX4BACE1 | |
| SCHEMBL7718298 | 0.74 | TRPA1 (0.32) | — | |
| SCHEMBL7713227 | 0.74 | CYP19A1 (0.37) | DRD2 | |
| SCHEMBL7718886 | 0.74 | MTNR1A (0.39) | DRD2DRD3SSTR4 | |
| SCHEMBL7486376 | 0.73 | DRD2 (0.58) | DRD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6384072-B1 | CARBAMYL SUBSTITUTED COMPOUNDS WITH ETHER GROUPS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2002-05-07 | — | — | US | disclosed |
| EP-1030834-A1 | BENZOCYCLOHEPTENE DERIVATIVES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2000-08-30 | — | — | EP | disclosed |
| WO-1999024397-A1 | BENZOCYCLOHEPTENE DERIVATIVES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1999-05-20 | — | — | WO | disclosed |