Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
| ▸ | KCNA5 | P22460 | 2/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.32 |
| ▸ | FAAH | O00519 | 1/20 | 0.31 |
| ▸ | PHGDH | O43175 | 1/20 | 0.31 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.31 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.31 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7713670 | 0.82 | ALDH1A1 (0.39) | KMT2AALDH1A1LMNAMAPTHPGD | |
| SCHEMBL16919618 | 0.77 | KMT2A (0.39) | KMT2AALDH1A1LMNAMAPTHPGD | |
| SCHEMBL9738640 | 0.77 | KMT2A (0.39) | KMT2AALDH1A1LMNAMAPTHPGD | |
| SCHEMBL8737569 | 0.76 | KMT2A (0.47) | KMT2AALDH1A1LMNAMAPTHPGD | |
| SCHEMBL232222 | 0.76 | KMT2A (0.47) | KMT2AALDH1A1LMNAMAPTHPGD | |
| SCHEMBL28169794 | 0.75 | KMT2A (0.35) | KMT2AALDH1A1LMNAMAPTHPGD | |
| SCHEMBL2284208 | 0.74 | ALDH1A1 (0.41) | KMT2AALDH1A1LMNAMAPTHPGD | |
| SCHEMBL2086387 | 0.74 | TSHR (0.42) | KMT2AALDH1A1LMNAMAPTHPGD | |
| SCHEMBL8557598 | 0.74 | KMT2A (0.37) | KMT2AALDH1A1LMNAMAPTHPGD | |
| SCHEMBL231163 | 0.74 | KMT2A (0.37) | KMT2AALDH1A1LMNAMAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002087587-A2 | 4-AMINOSULFONYLQUINAZOLINES AND -QUINOLINES AS TYROSINE KINASE INHIBITORS | CELLTECH R & D LIMITED (GB) | 2002-11-07 | — | — | WO | disclosed |