Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 4/20 | 0.59 |
| ▸ | RXRB | P28702 | 4/20 | 0.59 |
| ▸ | RXRG | P48443 | 1/20 | 0.47 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.44 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.44 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.44 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9239810 | 0.77 | RXRB (0.49) | RXRARXRBRXRGNR1H4ALDH1A1 | |
| SCHEMBL14372107 | 0.76 | GABRA1 (0.52) | RXRARXRBRXRGALDH1A1MAPT | |
| SCHEMBL179538 | 0.75 | RXRA (0.66) | RXRARXRBRXRGNR4A1NR4A2 | |
| SCHEMBL19987946 | 0.73 | RXRA (0.64) | RXRARXRBRXRGNR4A1NR4A2 | |
| SCHEMBL28102058 | 0.73 | CA12 (0.54) | RXRARXRBNR4A1ALDH1A1MAPT | |
| SCHEMBL7379122 | 0.71 | RXRA (0.45) | RXRARXRBNR4A1ALDH1A1MAPT | |
| SCHEMBL222176 | 0.71 | KMT2A (0.58) | ALDH1A1MAPTSMN1; SMN2MEN1NPC1 | |
| SCHEMBL29625195 | 0.71 | KMT2A (0.58) | ALDH1A1MAPTSMN1; SMN2MEN1NPC1 | |
| SCHEMBL17681587 | 0.70 | CA12 (0.47) | RXRARXRBNR4A1ALDH1A1MAPT | |
| SCHEMBL501957 | 0.70 | RXRB (0.64) | RXRARXRBRXRGNR1H4MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6376528-B1 | SYNERGISTIC MIXTURE | G. D. SEARLE & CO. | 2002-04-23 | — | — | US | disclosed |