Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 5/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.44 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.44 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.44 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.44 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.44 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.44 |
| ▸ | EGFR | P00533 | 2/20 | 0.40 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.35 |
| ▸ | CTSS | P25774 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7719351 | 1.00 | HDAC4 (0.46) | HDAC4HDAC1HDAC8HDAC3HDAC7 | |
| Methane SCHEMBL7718636 | 0.78 | HDAC4 (0.46) | HDAC4HDAC1HDAC8HDAC3HDAC7 | |
| SCHEMBL7718633 | 0.77 | ALDH1A1 (0.47) | HDAC4HDAC1HDAC8HDAC3HDAC7 | |
| Methane SCHEMBL7721379 | 0.72 | AAK1 (0.41) | HDAC4HDAC1HDAC8HDAC3HDAC7 | |
| SCHEMBL7721375 | 0.72 | KDM4E (0.43) | HDAC4HDAC1HDAC8HDAC3HDAC7 | |
| SCHEMBL15773911 | 0.69 | HSD17B10 (0.46) | HDAC4HDAC1HDAC8HDAC3HDAC7 | |
| SCHEMBL27613652 | 0.68 | HDAC4 (0.61) | HDAC4HDAC1HDAC8HDAC3HDAC7 | |
| SCHEMBL7709234 | 0.68 | TRPV1 (0.44) | KDM4E | |
| SCHEMBL7939509 | 0.68 | HDAC4 (0.48) | HDAC4HDAC1HDAC8HDAC3HDAC7 | |
| SCHEMBL7939513 | 0.68 | HDAC4 (0.48) | HDAC4HDAC1HDAC8HDAC3HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6441017-B1 | Inhibitors of prenyl-protein transferase | MERCK & CO., INC. | 2002-08-27 | — | — | US | disclosed |