Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | PLIN1 | O60240 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | PLIN5 | Q00G26 | 1/20 | 0.43 |
| ▸ | ABHD5 | Q8WTS1 | 1/20 | 0.43 |
| ▸ | CTSS | P25774 | 1/20 | 0.43 |
| ▸ | CTSK | P43235 | 1/20 | 0.43 |
| ▸ | AAK1 | Q2M2I8 | 4/20 | 0.40 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methane SCHEMBL7721379 | 0.89 | AAK1 (0.41) | KDM4EALDH1A1MAPTSMN1; SMN2CTSS | |
| SCHEMBL7718633 | 0.86 | ALDH1A1 (0.47) | KDM4EALDH1A1HPGDLMNATHRB | |
| SCHEMBL7714829 | 0.81 | AAK1 (0.38) | AAK1HDAC8HDAC3HDAC1HDAC2 | |
| Methane SCHEMBL7718636 | 0.75 | HDAC4 (0.46) | MAPTSMN1; SMN2CTSSCTSKAAK1 | |
| SCHEMBL31347280 | 0.72 | KMT2A (0.53) | KDM4EALDH1A1HPGDLMNATHRB | |
| SCHEMBL7719355 | 0.72 | HDAC4 (0.46) | KDM4EMAPTSMN1; SMN2CTSSCTSK | |
| SCHEMBL7719351 | 0.72 | HDAC4 (0.46) | KDM4EMAPTSMN1; SMN2CTSSCTSK | |
| SCHEMBL7936792 | 0.71 | KLK5 (0.50) | KDM4EALDH1A1HPGDLMNATHRB | |
| SCHEMBL6555173 | 0.70 | CTSS (0.52) | KDM4EALDH1A1HPGDLMNATHRB | |
| SCHEMBL6556874 | 0.70 | CTSS (0.54) | KDM4EALDH1A1HPGDLMNACA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6441017-B1 | Inhibitors of prenyl-protein transferase | MERCK & CO., INC. | 2002-08-27 | — | — | US | disclosed |