Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A | P35348 | 5/20 | 0.49 |
| ▸ | ADRA1D | P25100 | 4/20 | 0.49 |
| ▸ | ADRA1B | P35368 | 4/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | DRD2 | P14416 | 6/20 | 0.47 |
| ▸ | DRD4 | P21917 | 2/20 | 0.47 |
| ▸ | DRD3 | P35462 | 4/20 | 0.46 |
| ▸ | HTR7 | P34969 | 2/20 | 0.46 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6800835 | 0.88 | ADRA1A (0.49) | ADRA1AADRA1DADRA1BLMNADRD2 | |
| SCHEMBL7720561 | 0.87 | DRD3 (0.47) | ADRA1ADRD2DRD4DRD3HTR7 | |
| SCHEMBL7599425 | 0.84 | MTTP (0.38) | ADRA1ADRD2DRD4DRD3HTR7 | |
| SCHEMBL7597657 | 0.84 | MTTP (0.38) | ADRA1ADRD2DRD4DRD3HTR7 | |
| SCHEMBL7720317 | 0.83 | DRD2 (0.47) | ADRA1ADRD2DRD4DRD3HTR7 | |
| SCHEMBL7720550 | 0.82 | DRD2 (0.43) | ADRA1ADRD2DRD4DRD3HTR7 | |
| SCHEMBL7596831 | 0.82 | HTR1A (0.42) | ADRA1ADRD2DRD4DRD3HTR7 | |
| SCHEMBL7600219 | 0.81 | HTR1A (0.41) | ADRA1ADRD2DRD3 | |
| SCHEMBL7716462 | 0.81 | DRD3 (0.43) | ADRA1ADRD2DRD4DRD3HTR7 | |
| SCHEMBL7607061 | 0.81 | ALDH1A1 (0.44) | ADRA1ADRD2DRD3HTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1228053-A1 | SUBSTITUTED PIPERAZINE DERIVATIVES, THE PRODUCTION AND USE THEREOF AS INHIBITORS OF THE MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN (MTP) | Boehringer Ingelheim Pharma KG (DE) | 2002-08-07 | — | — | EP | disclosed |
| WO-2001021604-A1 | SUBSTITUTED PIPERAZINE DERIVATIVES, THE PRODUCTION THEREOF AND THEIR USE AS INHIBITORS OF THE MICROSOMAL TRIGLYCERIDE-TRANSFER PROTEIN (MTP) | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2001-03-29 | — | — | WO | disclosed |