Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | G6PD | P11413 | 1/20 | 0.36 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.36 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.36 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.36 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.36 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | CA1 | P00915 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16222419 | 0.91 | HIF1A (0.36) | HIF1AEPAS1MAPTKDM4EMAPK1 | |
| SCHEMBL16365919 | 0.88 | HIF1A (0.34) | HIF1AEPAS1MAPTKDM4EMAPK1 | |
| SCHEMBL14297115 | 0.88 | HIF1A (0.34) | HIF1AEPAS1MAPTKDM4EMAPK1 | |
| SCHEMBL14314327 | 0.88 | KDM4E (0.39) | HIF1AEPAS1MAPTKDM4EMAPK1 | |
| SCHEMBL16219591 | 0.87 | ALOX5AP (0.33) | HIF1AEPAS1MAPTALDH1A1GAA | |
| SCHEMBL16882305 | 0.84 | HIF1A (0.39) | HIF1AEPAS1MAPTKDM4EMAPK1 | |
| SCHEMBL7723490 | 0.79 | CYP1A2 (0.33) | MAPTCA1CA2CA7CA9 | |
| SCHEMBL14297124 | 0.79 | — | — | |
| SCHEMBL3447232 | 0.77 | CA2 (0.41) | MAPTKDM4EMAPK1HTTRAB9A | |
| SCHEMBL7721793 | 0.76 | ALDH1A1 (0.38) | MAPTKDM4EHTTALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1261573-A2 | ASYMMETRIC LIGANDS HAVING USE AS CATALYSTS | 1428388 Ontario Limited (CA) | 2002-12-04 | — | — | EP | claimed |
| WO-2001007386-A2 | ASYMMETRIC LIGANDS HAVING USE AS CATALYSTS | 1428388 ONTARIO LIMITED (CA) | 2001-02-01 | — | — | WO | claimed |
| US-9771386-B2 | Z-selective ring-closing metathesis reactions | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2017-09-26 | — | — | US | disclosed |
| US-20170129910-A1 | Z-SELECTIVE RING-CLOSING METATHESIS REACTIONS | NATIONAL INSTITUTES OF HEALTH, U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, U.S. GOVERNMENT | 2017-05-11 | — | — | US | disclosed |
| US-9446394-B2 | Z-selective ring-closing metathesis reactions | TRUSTEES OF BOSTON COLLEGE (US) | 2016-09-20 | — | — | US | disclosed |
| US-9441059-B2 | Metathesis catalysts and methods thereof | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2016-09-13 | — | — | US | disclosed |
| US-20150246348-A1 | Z-SELECTIVE RING-CLOSING METATHESIS REACTIONS | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 2015-09-03 | — | — | US | disclosed |
| US-9073801-B2 | Z-selective ring-closing metathesis reactions | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2015-07-07 | — | — | US | disclosed |
| US-20140378637-A1 | METATHESIS CATALYSTS AND METHODS THEREOF | NATIONAL SCIENCE FOUNDATION | 2014-12-25 | — | — | US | disclosed |
| US-20140330018-A1 | METATHESIS CATALYSTS AND METHODS THEREOF | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2014-11-06 | — | — | US | disclosed |
| EP-1261573-A2 | ASYMMETRIC LIGANDS HAVING USE AS CATALYSTS | 1428388 Ontario Limited (CA) | 2002-12-04 | — | — | EP | disclosed |
| WO-2001007386-A2 | ASYMMETRIC LIGANDS HAVING USE AS CATALYSTS | 1428388 ONTARIO LIMITED (CA) | 2001-02-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140330018-A1 | METATHESIS CATALYSTS AND METHODS THEREOF | TERT, CYP19A1, MPO | HIF1A 588/4885EPAS1 2016/4885MAPT 4037/4885 |
| US-20150246348-A1 | Z-SELECTIVE RING-CLOSING METATHESIS REACTIONS | ZYX, ZDHHC7, ZDHHC2 | HIF1A 3522/4885EPAS1 2777/4885MAPT 3406/4885 |
| US-20170129910-A1 | Z-SELECTIVE RING-CLOSING METATHESIS REACTIONS | ZYX, ZDHHC7, ZDHHC2 | HIF1A 3522/4885EPAS1 2777/4885MAPT 3406/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.