Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | UHRF1 | Q96T88 | 1/20 | 0.42 |
| ▸ | NOS3 | P29474 | 1/20 | 0.38 |
| ▸ | NOS1 | P29475 | 1/20 | 0.38 |
| ▸ | NOS2 | P35228 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 8/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 8/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 8/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8934135 | 0.79 | NOS3 (0.53) | UHRF1NOS3NOS1NOS2SLC6A2 | |
| SCHEMBL28198255 | 0.75 | UHRF1 (0.50) | UHRF1NOS3NOS1NOS2LMNA | |
| Hydrochloric Acid SCHEMBL8585446 | 0.74 | NOS3 (0.62) | NOS3NOS1NOS2LMNAKDM4E | |
| SCHEMBL10330646 | 0.73 | UHRF1 (0.48) | UHRF1NOS3NOS1NOS2LMNA | |
| SCHEMBL7724215 | 0.71 | LMNA (0.69) | LMNATSHRKDM4EALDH1A1 | |
| SCHEMBL22897579 | 0.70 | TDP1 (0.45) | SLC6A2SLC6A4SLC6A3KDM4EALDH1A1 | |
| SCHEMBL25908641 | 0.70 | UHRF1 (0.45) | UHRF1NOS3NOS1NOS2LMNA | |
| SCHEMBL11396782 | 0.69 | DHFR (0.54) | — | |
| SCHEMBL2135557 | 0.68 | ALDH1A1 (0.42) | LMNATSHRKDM4EALDH1A1HPGD | |
| SCHEMBL487644 | 0.68 | TSHR (0.39) | LMNATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6420367-B1 | RAS GENE | SHIONOGO & CO., LTD. (JP) | 2002-07-16 | — | — | US | disclosed |
| EP-1097933-A1 | PYRIMIDINE DERIVATIVES EXHIBITING ANTITUMOR ACTIVITY | SHIONOGI & CO., LTD. (JP) | 2001-05-09 | — | — | EP | disclosed |