Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 3/20 | 0.54 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.54 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.54 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.54 |
| ▸ | NPC1 | O15118 | 3/20 | 0.53 |
| ▸ | RAB9A | P51151 | 3/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.47 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.47 |
| ▸ | GABRP | O00591 | 1/20 | 0.47 |
| ▸ | GABRD | O14764 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.47 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.47 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.47 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7724767 | 0.92 | NPC1 (0.54) | PDE4APDE4BPDE4CPDE4DNPC1 | |
| SCHEMBL7723670 | 0.87 | MAPT (0.63) | PDE4APDE4BPDE4CPDE4DMAPT | |
| SCHEMBL7723486 | 0.81 | TACR3 (0.55) | PDE4APDE4BPDE4CPDE4DNPC1 | |
| SCHEMBL7730095 | 0.81 | MAPT (0.55) | PDE4APDE4BPDE4CPDE4DNPC1 | |
| SCHEMBL7720271 | 0.78 | MAPT (0.64) | PDE4APDE4BPDE4CPDE4DNPC1 | |
| SCHEMBL7724840 | 0.78 | MAPT (0.61) | PDE4APDE4BPDE4CPDE4DMAPT | |
| SCHEMBL1925273 | 0.78 | PDE4A (0.52) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7724970 | 0.77 | CRHR1 (0.49) | NPC1RAB9AMAPTGABRA1GABRB2 | |
| SCHEMBL7723615 | 0.77 | SMN1; SMN2 (0.44) | NPC1RAB9AMAPTGABRA1GABRB2 | |
| SCHEMBL5584601 | 0.77 | PDE4B (0.50) | PDE4APDE4BPDE4CPDE4DDHODH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6403586-B1 | Pyridazine derivatives and drugs containing the same as the active ingredient | KOWA CO., LTD. (JP) | 2002-06-11 | — | — | US | disclosed |
| EP-1061077-A1 | NOVEL PYRIDAZINE DERIVATIVES AND DRUGS CONTAINING THE SAME AS THE ACTIVE INGREDIENT | Kowa Co., Ltd. (JP) | 2000-12-20 | — | — | EP | disclosed |