Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR3 | P29371 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | PDE4A | P27815 | 3/20 | 0.48 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.48 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.48 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | ELANE | P08246 | 2/20 | 0.45 |
| ▸ | DHODH | Q02127 | 1/20 | 0.44 |
| ▸ | FAAH | O00519 | 1/20 | 0.43 |
| ▸ | MGLL | Q99685 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7730095 | 0.93 | MAPT (0.55) | TACR3NPC1RAB9APDE4APDE4B | |
| SCHEMBL7724767 | 0.82 | NPC1 (0.54) | NPC1RAB9APDE4APDE4BPDE4C | |
| SCHEMBL7723462 | 0.81 | PDE4A (0.54) | NPC1RAB9APDE4APDE4BPDE4C | |
| SCHEMBL7730352 | 0.81 | MAPT (0.67) | TACR3RAB9APDE4APDE4BPDE4C | |
| SCHEMBL7730092 | 0.80 | TACR3 (0.49) | TACR3MAPTELANEDHODHLMNA | |
| SCHEMBL7730090 | 0.80 | TACR3 (0.49) | TACR3MAPTELANEDHODHLMNA | |
| SCHEMBL7720142 | 0.72 | MAPT (0.55) | PDE4APDE4BPDE4CPDE4DMAPT | |
| SCHEMBL7730177 | 0.71 | L3MBTL1 (0.49) | RAB9AMAPTFAAHLMNA | |
| SCHEMBL7730097 | 0.71 | LMNA (0.48) | NPC1RAB9AMAPTLMNA | |
| SCHEMBL17379994 | 0.71 | TACR3 (1.00) | TACR3NPC1RAB9ADHODH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6403586-B1 | Pyridazine derivatives and drugs containing the same as the active ingredient | KOWA CO., LTD. (JP) | 2002-06-11 | — | — | US | disclosed |
| EP-1061077-A1 | NOVEL PYRIDAZINE DERIVATIVES AND DRUGS CONTAINING THE SAME AS THE ACTIVE INGREDIENT | Kowa Co., Ltd. (JP) | 2000-12-20 | — | — | EP | disclosed |