Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.51 |
| ▸ | TACR3 | P29371 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | MET | P08581 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | APEX1 | P27695 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | PDE4A | P27815 | 1/20 | 0.45 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7730095 | 0.89 | MAPT (0.55) | MAPTSMN1; SMN2POLBTDP1TACR3 | |
| SCHEMBL7724966 | 0.84 | MAPT (0.76) | MAPTSMN1; SMN2POLBTDP1ALDH1A1 | |
| SCHEMBL7720142 | 0.83 | MAPT (0.55) | MAPTSMN1; SMN2HDAC1KMT2AMEN1 | |
| SCHEMBL7730177 | 0.82 | L3MBTL1 (0.49) | MAPTPOLBKMT2AALDH1A1LMNA | |
| SCHEMBL7730097 | 0.82 | LMNA (0.48) | MAPTSMN1; SMN2POLBTDP1KMT2A | |
| SCHEMBL7723486 | 0.81 | TACR3 (0.55) | MAPTHDAC1TACR3LMNARAB9A | |
| SCHEMBL7724756 | 0.81 | MAPT (0.53) | MAPTSMN1; SMN2HDAC1ALDH1A1LMNA | |
| SCHEMBL7720271 | 0.80 | MAPT (0.64) | MAPTSMN1; SMN2POLBTDP1HDAC1 | |
| SCHEMBL7723670 | 0.80 | MAPT (0.63) | MAPTSMN1; SMN2POLBTDP1HDAC1 | |
| SCHEMBL7723477 | 0.79 | KMT2A (0.47) | MAPTSMN1; SMN2POLBKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6403586-B1 | Pyridazine derivatives and drugs containing the same as the active ingredient | KOWA CO., LTD. (JP) | 2002-06-11 | — | — | US | disclosed |
| EP-1061077-A1 | NOVEL PYRIDAZINE DERIVATIVES AND DRUGS CONTAINING THE SAME AS THE ACTIVE INGREDIENT | Kowa Co., Ltd. (JP) | 2000-12-20 | — | — | EP | disclosed |