Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | RAB9A | P51151 | 4/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.50 |
| ▸ | BRAF | P15056 | 1/20 | 0.50 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.50 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.50 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.50 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.50 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.50 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.50 |
| ▸ | SNCA | P37840 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7726291 | 0.93 | SMN1; SMN2 (0.55) | SMN1; SMN2LMNAMAPTRAB9AHDAC1 | |
| SCHEMBL7720167 | 0.87 | KMT2A (0.53) | SMN1; SMN2MAPTRAB9AKMT2ANPC1 | |
| SCHEMBL7720270 | 0.82 | MAPT (0.59) | SMN1; SMN2LMNAMAPTRAB9AHDAC1 | |
| SCHEMBL7723619 | 0.78 | KMT2A (0.54) | SMN1; SMN2MAPTRAB9AKMT2ANPC1 | |
| SCHEMBL7720288 | 0.77 | MAPT (0.66) | SMN1; SMN2MAPTRAB9AHDAC1KMT2A | |
| SCHEMBL7725155 | 0.75 | JAK2 (0.47) | LMNAMAPTRAB9AKMT2ANPC1 | |
| SCHEMBL11195433 | 0.75 | KMT2A (0.80) | SMN1; SMN2LMNAMAPTRAB9AKMT2A | |
| SCHEMBL7726296 | 0.73 | JAK2 (0.45) | LMNAMAPTRAB9AKMT2ANPC1 | |
| SCHEMBL7724719 | 0.73 | JAK2 (0.45) | SMN1; SMN2LMNAMAPTRAB9AKMT2A | |
| SCHEMBL7730172 | 0.73 | LMNA (0.51) | LMNAMAPTRAB9AKMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6403586-B1 | Pyridazine derivatives and drugs containing the same as the active ingredient | KOWA CO., LTD. (JP) | 2002-06-11 | — | — | US | disclosed |
| EP-1061077-A1 | NOVEL PYRIDAZINE DERIVATIVES AND DRUGS CONTAINING THE SAME AS THE ACTIVE INGREDIENT | Kowa Co., Ltd. (JP) | 2000-12-20 | — | — | EP | disclosed |