Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | BRD4 | O60885 | 1/20 | 0.46 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.45 |
| ▸ | GSK3B | P49841 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | MARS1 | P56192 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.43 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.43 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7723619 | 0.90 | KMT2A (0.54) | KMT2ATDP1NPC1RAB9AGAA | |
| SCHEMBL7720270 | 0.89 | MAPT (0.59) | KMT2ANPC1RAB9AMEN1MAPT | |
| SCHEMBL7723571 | 0.87 | SMN1; SMN2 (0.56) | KMT2ATDP1NPC1RAB9AGAA | |
| SCHEMBL7725155 | 0.81 | JAK2 (0.47) | KMT2ATDP1NPC1RAB9AKDM4E | |
| SCHEMBL7720288 | 0.80 | MAPT (0.66) | KMT2ARAB9AMEN1KDM4EMAPT | |
| SCHEMBL7726296 | 0.79 | JAK2 (0.45) | KMT2ATDP1NPC1RAB9AMEN1 | |
| SCHEMBL7730172 | 0.79 | LMNA (0.51) | KMT2ATDP1RAB9AMEN1KDM4E | |
| SCHEMBL7724719 | 0.79 | JAK2 (0.45) | KMT2ATDP1NPC1RAB9AKDM4E | |
| SCHEMBL7726291 | 0.79 | SMN1; SMN2 (0.55) | KMT2ATDP1NPC1RAB9AGAA | |
| SCHEMBL7720271 | 0.79 | MAPT (0.64) | KMT2ATDP1NPC1RAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6403586-B1 | Pyridazine derivatives and drugs containing the same as the active ingredient | KOWA CO., LTD. (JP) | 2002-06-11 | — | — | US | disclosed |
| EP-1061077-A1 | NOVEL PYRIDAZINE DERIVATIVES AND DRUGS CONTAINING THE SAME AS THE ACTIVE INGREDIENT | Kowa Co., Ltd. (JP) | 2000-12-20 | — | — | EP | disclosed |