Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.66 |
| ▸ | BRD4 | O60885 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | PSD | A5PKW4 | 2/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | CNR1 | P21554 | 1/20 | 0.43 |
| ▸ | CNR2 | P34972 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7726400 | 0.90 | MAPT (0.68) | MAPTSMN1; SMN2HTTPSDHDAC1 | |
| SCHEMBL7720270 | 0.86 | MAPT (0.59) | MAPTSMN1; SMN2BRD4HTTHDAC1 | |
| SCHEMBL7725155 | 0.81 | JAK2 (0.47) | MAPTBRD4HTTALDH1A1KDM4E | |
| SCHEMBL7720167 | 0.80 | KMT2A (0.53) | MAPTSMN1; SMN2BRD4ALDH1A1KDM4E | |
| SCHEMBL7726296 | 0.79 | JAK2 (0.45) | MAPTBRD4HTTALDH1A1KDM4E | |
| SCHEMBL7730172 | 0.79 | LMNA (0.51) | MAPTALDH1A1KDM4EMEN1POLB | |
| SCHEMBL7724719 | 0.79 | JAK2 (0.45) | MAPTSMN1; SMN2HTTALDH1A1KDM4E | |
| SCHEMBL7724936 | 0.78 | MALT1 (0.44) | MAPTSMN1; SMN2ALDH1A1MEN1POLB | |
| SCHEMBL7720154 | 0.78 | JAK2 (0.44) | MAPTBRD4HTTHDAC1ALDH1A1 | |
| SCHEMBL7723571 | 0.77 | SMN1; SMN2 (0.56) | MAPTSMN1; SMN2HTTHDAC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6403586-B1 | Pyridazine derivatives and drugs containing the same as the active ingredient | KOWA CO., LTD. (JP) | 2002-06-11 | — | — | US | disclosed |
| EP-1061077-A1 | NOVEL PYRIDAZINE DERIVATIVES AND DRUGS CONTAINING THE SAME AS THE ACTIVE INGREDIENT | Kowa Co., Ltd. (JP) | 2000-12-20 | — | — | EP | disclosed |