Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.45 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.43 |
| ▸ | HTR1D | P28221 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | HTR6 | P50406 | 1/20 | 0.42 |
| ▸ | ICMT | O60725 | 2/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7734107 | 0.86 | ICMT (0.50) | KDM4EALDH1A1LMNATP53RXFP1 | |
| SCHEMBL7734844 | 0.85 | KDM4E (0.51) | KDM4EALDH1A1LMNATP53RXFP1 | |
| SCHEMBL5241306 | 0.85 | ADRB2 (0.54) | KDM4EALDH1A1LMNATP53RXFP1 | |
| SCHEMBL5239371 | 0.84 | ADRB2 (0.52) | KDM4EALDH1A1LMNATP53RXFP1 | |
| SCHEMBL8259649 | 0.82 | ADRB2 (0.46) | KDM4ERXFP1ADRB2HTR1DHTR6 | |
| SCHEMBL5923660 | 0.81 | ADRB2 (0.64) | KDM4EALDH1A1LMNATP53RXFP1 | |
| SCHEMBL21614279 | 0.81 | KDM4E (0.50) | KDM4EALDH1A1LMNATP53RXFP1 | |
| SCHEMBL7828706 | 0.80 | LMNA (0.56) | KDM4EALDH1A1LMNATP53RXFP1 | |
| Hydrochloric Acid SCHEMBL16592500 | 0.80 | ADRB2 (0.62) | KDM4EALDH1A1LMNATP53RXFP1 | |
| SCHEMBL18508879 | 0.79 | KDM4E (0.58) | KDM4EALDH1A1LMNATP53RXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6828325-B2 | A benzoxazolopiperazine derivative useful for treating Parkinson's diseases, schizophrenia, anxiety and depression | SOLVAY PHARMACEUTICALS B.V. (CH) | 2004-12-07 | — | — | US | disclosed |
| US-6828325-B2 | A benzoxazolopiperazine derivative useful for treating Parkinson's diseases, schizophrenia, anxiety and depression | SOLVAY PHARMACEUTICALS B.V. (CH) | 2004-12-07 | — | — | US | disclosed |