Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 2/20 | 0.52 |
| ▸ | HTR1D | P28221 | 1/20 | 0.52 |
| ▸ | MPO | P05164 | 4/20 | 0.50 |
| ▸ | HTR2A | P28223 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | HTR6 | P50406 | 1/20 | 0.41 |
| ▸ | ICMT | O60725 | 2/20 | 0.41 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5241306 | 0.95 | ADRB2 (0.54) | ADRB2HTR1DMPOHTR2AKDM4E | |
| SCHEMBL5923660 | 0.89 | ADRB2 (0.64) | ADRB2HTR1DMPOHTR2AKDM4E | |
| Hydrochloric Acid SCHEMBL16592500 | 0.88 | ADRB2 (0.62) | ADRB2HTR1DMPOHTR2AKDM4E | |
| SCHEMBL7734107 | 0.85 | ICMT (0.50) | ADRB2HTR1DMPOHTR2AKDM4E | |
| Cadaverine Tartrate SCHEMBL3703327 | 0.84 | LMNA (0.45) | ADRB2HTR1DMPOHTR2AKDM4E | |
| SCHEMBL7734844 | 0.84 | KDM4E (0.51) | ADRB2HTR1DHTR2AKDM4EALDH1A1 | |
| SCHEMBL7723955 | 0.84 | KDM4E (0.48) | ADRB2HTR1DHTR2AKDM4EALDH1A1 | |
| SCHEMBL21614279 | 0.80 | KDM4E (0.50) | ADRB2HTR1DHTR2AKDM4EALDH1A1 | |
| SCHEMBL3705622 | 0.79 | ICMT (0.55) | MPOHTR6ICMT | |
| SCHEMBL7828706 | 0.79 | LMNA (0.56) | MPOKDM4EALDH1A1LMNATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101143867-A | Antidepressant indolealkyl derivatves of heterocyclefused benzodioxan methylamines | WYETH CORP (US) | 2008-03-19 | — | — | CN | disclosed |
| CN-100358898-C | Antidepressant indolealkyl derivatives of heterocycle-fused benzodi * alkylmethylamines | WYETH CORP (US) | 2008-01-02 | — | — | CN | disclosed |
| EP-1537122-B9 | ANTIDEPRESSANT INDOLEALKYL DERIVATIVES OF HETEROCYCLE-FUSED BENZODIOXAN METHYLAMINES | WYETH CORP (US) | 2007-10-31 | — | — | EP | disclosed |
| EP-1537122-B1 | ANTIDEPRESSANT INDOLEALKYL DERIVATIVES OF HETEROCYCLE-FUSED BENZODIOXAN METHYLAMINES | WYETH CORP (US) | 2007-08-22 | — | — | EP | disclosed |
| CN-1701075-A | Antidepressant indolealkyl derivatives of heterocycle-fused benzodioxan methylamines | WYETH CORP (US) | 2005-11-23 | — | — | CN | disclosed |
| EP-1537122-A1 | ANTIDEPRESSANT INDOLEALKYL DERIVATIVES OF HETEROCYCLE-FUSED BENZODIOXAN METHYLAMINES | Wyeth (US) | 2005-06-08 | — | — | EP | disclosed |
| US-6800637-B2 | Antidepressant indolealkyl derivatives of heterocycle-fused benzodioxan methylamines | WYETH | 2004-10-05 | — | — | US | disclosed |
| US-20040138222-A1 | Antidepressant indolealkyl derivatives of heterocycle-fused benzodioxan methylamines | WYETH | 2004-07-15 | — | — | US | disclosed |
| WO-2004024734-A1 | ANTIDEPRESSANT INDOLEALKYL DERIVATIVES OF HETEROCYCLE-FUSED BENZODIOXAN METHYLAMINES | WYETH (US) | 2004-03-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040138222-A1 | Antidepressant indolealkyl derivatives of heterocycle-fused benzodioxan methylamines | HTR5A, TPH1, DBH | ADRB2 126/4885HTR1D 15/4885MPO 1008/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.