Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.53 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | PDE4A | P27815 | 2/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.47 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | NPBWR1 | P48145 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7726527 | 0.81 | CRHR1 (0.45) | PDE4APDE4BPDE4CPDE4DNPC1 | |
| SCHEMBL7720181 | 0.81 | MAPT (0.53) | MAPTADORA2AHDAC1SMN1; SMN2PDE4A | |
| SCHEMBL7730352 | 0.81 | MAPT (0.67) | MAPTADORA2AHDAC1SMN1; SMN2PDE4A | |
| SCHEMBL7726116 | 0.80 | ADORA2A (0.61) | MAPTADORA2AHDAC1SMN1; SMN2PDE4A | |
| SCHEMBL7720142 | 0.80 | MAPT (0.55) | MAPTADORA2AHDAC1SMN1; SMN2PDE4A | |
| SCHEMBL7720271 | 0.78 | MAPT (0.64) | MAPTADORA2AHDAC1SMN1; SMN2PDE4A | |
| SCHEMBL7723670 | 0.78 | MAPT (0.63) | MAPTADORA2AHDAC1SMN1; SMN2PDE4A | |
| SCHEMBL23297368 | 0.77 | PDE4B (0.71) | MAPTADORA2AHDAC1SMN1; SMN2PDE4A | |
| SCHEMBL7720270 | 0.77 | MAPT (0.59) | MAPTADORA2AHDAC1SMN1; SMN2PDE4A | |
| SCHEMBL7995817 | 0.76 | MAPT (0.63) | MAPTADORA2ASMN1; SMN2PDE4APDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6403586-B1 | Pyridazine derivatives and drugs containing the same as the active ingredient | KOWA CO., LTD. (JP) | 2002-06-11 | — | — | US | disclosed |
| EP-1061077-A1 | NOVEL PYRIDAZINE DERIVATIVES AND DRUGS CONTAINING THE SAME AS THE ACTIVE INGREDIENT | Kowa Co., Ltd. (JP) | 2000-12-20 | — | — | EP | disclosed |