Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.40 |
| ▸ | PDE5A | O76074 | 2/20 | 0.39 |
| ▸ | PDE4A | P27815 | 2/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.39 |
| ▸ | ACP1 | P24666 | 1/20 | 0.39 |
| ▸ | PTGIR | P43119 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7724756 | 0.81 | MAPT (0.53) | L3MBTL1LMNANPC1RAB9ANPBWR1 | |
| SCHEMBL7724783 | 0.81 | L3MBTL1 (0.44) | CRHR1L3MBTL1GRIN1GRIN2BNPC1 | |
| SCHEMBL7730177 | 0.81 | L3MBTL1 (0.49) | CRHR1L3MBTL1LMNARAB9APTGIR | |
| SCHEMBL7720163 | 0.80 | L3MBTL1 (0.49) | CRHR1L3MBTL1GRIN1GRIN2BNPC1 | |
| SCHEMBL7724785 | 0.80 | LMNA (0.45) | CRHR1L3MBTL1LMNANPC1RAB9A | |
| SCHEMBL7724970 | 0.77 | CRHR1 (0.49) | CRHR1L3MBTL1LMNANPC1RAB9A | |
| SCHEMBL7723523 | 0.77 | CRHR1 (0.51) | CRHR1L3MBTL1BRD4GRIN1GRIN2B | |
| SCHEMBL7720077 | 0.76 | CASP1 (0.48) | CRHR1L3MBTL1GRIN1GRIN2BLMNA | |
| SCHEMBL7727026 | 0.76 | CRHR1 (0.50) | CRHR1L3MBTL1NPC1RAB9APTGIR | |
| SCHEMBL7723691 | 0.75 | CRHR1 (0.49) | CRHR1L3MBTL1GRIN1GRIN2BLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6403586-B1 | Pyridazine derivatives and drugs containing the same as the active ingredient | KOWA CO., LTD. (JP) | 2002-06-11 | — | — | US | disclosed |
| EP-1061077-A1 | NOVEL PYRIDAZINE DERIVATIVES AND DRUGS CONTAINING THE SAME AS THE ACTIVE INGREDIENT | Kowa Co., Ltd. (JP) | 2000-12-20 | — | — | EP | disclosed |