Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.43 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.43 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.42 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.42 |
| ▸ | SLC16A1 | P53985 | 1/20 | 0.42 |
| ▸ | MCTS1 | Q9ULC4 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7723449 | 0.86 | MAPT (0.53) | KMT2APLA2G2AMAPTSMN1; SMN2MEN1 | |
| SCHEMBL7720270 | 0.83 | MAPT (0.59) | MALT1KMT2AMAPTSMN1; SMN2MEN1 | |
| SCHEMBL7725155 | 0.81 | JAK2 (0.47) | KMT2AMAPTNPC1RAB9AALDH1A1 | |
| SCHEMBL7724719 | 0.79 | JAK2 (0.45) | KMT2AMAPTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL7726296 | 0.79 | JAK2 (0.45) | KMT2AMAPTMEN1NPC1RAB9A | |
| SCHEMBL7730172 | 0.79 | LMNA (0.51) | KMT2AMAPTMEN1RAB9ARXFP1 | |
| SCHEMBL7723562 | 0.79 | MALT1 (0.45) | MALT1KMT2APLA2G2AMAPTSMN1; SMN2 | |
| SCHEMBL7723561 | 0.79 | MALT1 (0.45) | MALT1KMT2APLA2G2AMAPTSMN1; SMN2 | |
| SCHEMBL7720154 | 0.79 | JAK2 (0.44) | KMT2AMAPTNPC1RAB9APOLB | |
| SCHEMBL7720288 | 0.78 | MAPT (0.66) | KMT2AMAPTSMN1; SMN2MEN1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6403586-B1 | Pyridazine derivatives and drugs containing the same as the active ingredient | KOWA CO., LTD. (JP) | 2002-06-11 | — | — | US | disclosed |
| EP-1061077-A1 | NOVEL PYRIDAZINE DERIVATIVES AND DRUGS CONTAINING THE SAME AS THE ACTIVE INGREDIENT | Kowa Co., Ltd. (JP) | 2000-12-20 | — | — | EP | disclosed |