Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydroxyphenyl Propionic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 known ✓ | P03372 | 1/20 | 0.52 |
| ▸ | ESR2 known ✓ | Q92731 | 1/20 | 0.52 |
| ▸ | FFAR1 | O14842 | 11/20 | 0.61 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.59 |
| ▸ | CA2 | P00918 | 2/20 | 0.54 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | F13A1 | P00488 | 1/20 | 0.53 |
| ▸ | FFAR4 | Q5NUL3 | 3/20 | 0.53 |
| ▸ | CA1 | P00915 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydroxyphenyl Propionic Acid SCHEMBL28123368 | 0.94 | FFAR1 (0.63) | FFAR1KEAP1CA2CAMK2AKDM4E | |
| Hydroxyphenyl Propionic Acid SCHEMBL35486 | 0.94 | FFAR1 (0.68) | FFAR1KEAP1CA2CAMK2AKDM4E | |
| Hydroxyphenyl Propionic Acid SCHEMBL18263865 | 0.91 | FFAR1 (0.65) | FFAR1KEAP1CA2CAMK2AKDM4E | |
| Hydroxyphenyl Propionic Acid SCHEMBL10712090 | 0.91 | FFAR1 (0.65) | FFAR1KEAP1CA2CAMK2AKDM4E | |
| Hydroxyphenyl Propionic Acid SCHEMBL28184441 | 0.91 | FFAR1 (0.65) | FFAR1KEAP1CA2CAMK2AKDM4E | |
| Hydroxyphenyl Propionic Acid SCHEMBL5606896 | 0.91 | FFAR1 (0.65) | FFAR1KEAP1CA2CAMK2AKDM4E | |
| Hydroxyphenyl Propionic Acid SCHEMBL10765619 | 0.90 | L3MBTL1 (0.59) | FFAR1KEAP1CA2CAMK2AKDM4E | |
| SCHEMBL3293457 | 0.88 | FFAR1 (0.74) | FFAR1KEAP1CA2CAMK2AFFAR4 | |
| Raspberryketone SCHEMBL593164 | 0.88 | ALDH1A1 (0.67) | FFAR1CA2CAMK2AKDM4EF13A1 | |
| Hydroxyphenyl Propionic Acid SCHEMBL7727271 | 0.86 | CA2 (0.76) | FFAR1KEAP1CA2CAMK2AFFAR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6409937-B1 | 4-HYDROXYPHENYLACETIC ACID, 3-(4-HYDROXYPHENYL)PROPIONIC ACID, TEREPHTHALIC ACID, HYDROQUINONE, 2,6-NAPHTHALENE DIOL, 4,4'-BIPHENOL; ACETYLATION, HYDROLYSIS AT REDUCED PRESSURE FOR EFFICIENT ACETIC ACID REMOVAL AND HIGHER MOLECULAR WEIGHT | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2002-06-25 | — | — | US | disclosed |
| JP-2001278968-A | THERMOTROPIC LIQUID CRYSTAL TERPOLYESTER CAPABLE OF MELT PROCESSING AND MANUFACTURING OF THE SAME | COUNCIL SCIENT IND RES | 2001-10-10 | — | — | JP | disclosed |