SCHEMBL7728989

SCHEMBL7728989

O=C(Cl)c1c(F)c(F)c(F)c(F)c1F.O=C(Cl)c1ccccc1F

nearest known ligand 0.77

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.77
ALOX15 P16050 1/20 0.77
CES2 O00748 4/20 0.52
CES1 P23141 4/20 0.52
GAA P10253 2/20 0.44
BCHE P06276 1/20 0.44
MEN1 O00255 2/20 0.43
KMT2A Q03164 2/20 0.43
TDP1 Q9NUW8 1/20 0.43
NPC1 O15118 2/20 0.42
HPGD P15428 2/20 0.42
MAPT P10636 1/20 0.42
RAB9A P51151 2/20 0.41
PTPN1 P18031 1/20 0.41
ERCC5 P28715 1/20 0.41
FEN1 P39748 1/20 0.41
SMN1; SMN2 Q16637 1/20 0.41
LMNA P02545 2/20 0.40
HTT P42858 2/20 0.40
TP53 P04637 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30733529 0.88 ALDH1A1 (1.00) ALDH1A1ALOX15CES2CES1GAA
SCHEMBL60101 0.88 ALDH1A1 (1.00) ALDH1A1ALOX15CES2CES1GAA
Methylene Chloride SCHEMBL27984894 0.82 ALDH1A1 (0.87) ALDH1A1ALOX15CES2CES1GAA
1,1,2,2-Tetrachloroethane SCHEMBL27984880 0.80 ALDH1A1 (0.83) ALDH1A1ALOX15CES2CES1GAA
SCHEMBL7621298 0.78 CES2 (0.55) ALDH1A1ALOX15CES2CES1NPC1
SCHEMBL9836255 0.78 ALDH1A1 (0.65) ALDH1A1ALOX15CES2CES1GAA
SCHEMBL8702458 0.77 CES2 (0.59) ALDH1A1ALOX15CES2CES1BCHE
SCHEMBL9712558 0.76 ALDH1A1 (0.76) ALDH1A1ALOX15CES2CES1GAA
SCHEMBL1657 0.76 CES2 (0.48) ALDH1A1ALOX15CES2CES1GAA
SCHEMBL27984879 0.76 ALDH1A1 (0.74) ALDH1A1ALOX15CES2CES1GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1015479-A4 COMBINATORIAL LIBRARIES OF PEPTIDOMIMETIC MACROCYCLES AND PROCESSES THEREFOR LILLY CO ELI (US) 2002-07-24 EP disclosed
EP-1015479-A1 COMBINATORIAL LIBRARIES OF PEPTIDOMIMETIC MACROCYCLES AND PROCESSES THEREFOR ELI LILLY AND COMPANY (US) 2000-07-05 EP disclosed
EP-0973936-A1 COMBINATORIAL LIBRARIES OF PEPTIDOMIMETIC AMINOTHIOETHER ACIDS ELI LILLY AND COMPANY (US) 2000-01-26 EP disclosed
WO-1998057173-A1 COMBINATORIAL PROCESS FOR PREPARING SUBSTITUTED PHENYLALANINE LIBRARIES ELI LILLY AND COMPANY (US) 1998-12-17 WO disclosed
WO-1998046631-A1 COMBINATORIAL LIBRARIES OF PEPTIDOMIMETIC MACROCYCLES AND PROCESSES THEREFOR ELI LILLY AND COMPANY (US) 1998-10-22 WO disclosed
WO-1998046786-A1 COMBINATORIAL LIBRARIES OF PEPTIDOMIMETIC AMINOTHIOETHER ACIDS ELI LILLY AND COMPANY (US) 1998-10-22 WO disclosed
WO-1998008839-A1 COMBINATORIAL PROCESS FOR PREPARING SUBSTITUTED THIOPHENE LIBRARIES ELI LILLY AND COMPANY (US) 1998-03-05 WO disclosed
WO-1998008813-A1 COMBINATORIAL PROCESS FOR PREPARING SUBSTITUTED PYRROLIDINE LIBRARIES ELI LILLY AND COMPANY (US) 1998-03-05 WO disclosed