Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.48 |
| ▸ | DRD2 | P14416 | 1/20 | 0.47 |
| ▸ | DRD4 | P21917 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 2/20 | 0.46 |
| ▸ | HTR2C | P28335 | 2/20 | 0.46 |
| ▸ | HTR7 | P34969 | 2/20 | 0.46 |
| ▸ | HTR6 | P50406 | 1/20 | 0.46 |
| ▸ | CCR3 | P51677 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7729412 | 1.00 | SIGMAR1 (0.48) | SIGMAR1DRD2DRD4HTR2AHTR2C | |
| SCHEMBL7724234 | 0.90 | DRD2 (0.45) | SIGMAR1DRD2DRD4HTR2AHTR2C | |
| SCHEMBL7724237 | 0.90 | DRD2 (0.45) | SIGMAR1DRD2DRD4HTR2AHTR2C | |
| SCHEMBL7729521 | 0.82 | DRD2 (0.45) | SIGMAR1DRD2DRD4HTR2AHTR2C | |
| SCHEMBL7729514 | 0.82 | DRD2 (0.45) | SIGMAR1DRD2DRD4HTR2AHTR2C | |
| SCHEMBL7723166 | 0.81 | HTR2A (0.52) | SIGMAR1DRD2DRD4HTR2AHTR2C | |
| SCHEMBL7723172 | 0.81 | HTR2A (0.52) | SIGMAR1DRD2DRD4HTR2AHTR2C | |
| SCHEMBL7724283 | 0.79 | CCR3 (0.50) | DRD2DRD4HTR2AHTR2CHTR7 | |
| SCHEMBL7724290 | 0.79 | CCR3 (0.50) | DRD2DRD4HTR2AHTR2CHTR7 | |
| SCHEMBL7729558 | 0.78 | CCR1 (0.60) | SIGMAR1DRD4HTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6468998-B1 | ANTAGONIZE SEROTONIN 2 RECEPTORS, SUPPRESS PLATELET AGGREGATION, IMPROVE PERIPHERAL CIRCULATION AND PROMOTE LACHRYMATION | MITSUBISHI PHARMA CORPORATION (JP) | 2002-10-22 | — | — | US | disclosed |
| EP-1125922-A1 | PYRROLIDINE COMPOUNDS AND MEDICINAL UTILIZATION THEREOF | Welfide Corporation (JP) | 2001-08-22 | — | — | EP | disclosed |