SCHEMBL7731071

SCHEMBL7731071

CC(C)(C)OC(=O)NCCC[C@@H](N)C(=O)N(C(=O)OC(C)(C)C)[C@H](CCc1ccccc1)C(O)c1nc2ccccc2[nH]1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
BCHE P06276 1/20 0.45
MMP1 P03956 1/20 0.38
MMP3 P08254 1/20 0.38
MMP9 P14780 1/20 0.38
BRD4 O60885 1/20 0.38
HDAC3 O15379 1/20 0.38
HDAC4 P56524 1/20 0.38
HDAC1 Q13547 1/20 0.38
HDAC7 Q8WUI4 1/20 0.38
HDAC2 Q92769 1/20 0.38
HDAC10 Q969S8 1/20 0.38
HDAC11 Q96DB2 1/20 0.38
HDAC8 Q9BY41 1/20 0.38
HDAC6 Q9UBN7 1/20 0.38
HDAC9 Q9UKV0 1/20 0.38
HDAC5 Q9UQL6 1/20 0.38
ADORA3 P0DMS8 6/20 0.37
CTSK P43235 2/20 0.37
PTPN1 P18031 1/20 0.36
SIGMAR1 Q99720 2/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7732168 0.84 ADORA3 (0.37) MMP1MMP3MMP9BRD4HDAC3
SCHEMBL7731104 0.83 MAPT (0.39) MMP1MMP3MMP9BRD4ADORA3
SCHEMBL7723247 0.79 MAPT (0.38) MMP1MMP3MMP9BRD4CTSK
SCHEMBL7735575 0.78 MAPT (0.37) MMP1MMP3MMP9BRD4ADORA3
SCHEMBL7731051 0.78 LMNA (0.39) MMP1MMP3MMP9BRD4HDAC8
SCHEMBL7723226 0.78 MAPT (0.38) MMP1MMP3MMP9ADORA3CTSK
SCHEMBL29642307 0.77 BCHE (0.60) BCHEBRD4HDAC3HDAC4HDAC1
SCHEMBL20232505 0.77 BCHE (0.60) BCHEBRD4HDAC3HDAC4HDAC1
SCHEMBL22598624 0.75 BCHE (0.59) BCHEBRD4HDAC3HDAC4HDAC1
SCHEMBL7723327 0.71 MAPT (0.44) MMP1MMP3MMP9ADORA3CTSK

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6436980-B1 TRANSPORT PROTEIN SUPPRESSORS; MICROBIOCIDES ESSENTIAL THERAPEUTICS, INC. 2002-08-20 US disclosed
US-6204279-B1 SECONDARY AMIDE CONTAINING BENZOXAZOLE DERIVATIVES MICROCIDE PHARMACEUTICALS, INC. 2001-03-20 US disclosed