Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | MMP1 | P03956 | 1/20 | 0.35 |
| ▸ | MMP3 | P08254 | 1/20 | 0.35 |
| ▸ | MMP9 | P14780 | 1/20 | 0.35 |
| ▸ | CTSK | P43235 | 2/20 | 0.35 |
| ▸ | BRD4 | O60885 | 6/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.34 |
| ▸ | CTSS | P25774 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | XBP1 | P17861 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7731104 | 0.91 | MAPT (0.39) | MAPTNPSR1MMP1MMP3MMP9 | |
| SCHEMBL7731051 | 0.90 | LMNA (0.39) | MAPTNPSR1MMP1MMP3MMP9 | |
| SCHEMBL7735575 | 0.90 | MAPT (0.37) | MAPTNPSR1MMP1MMP3MMP9 | |
| SCHEMBL7723226 | 0.86 | MAPT (0.38) | MAPTNPSR1MMP1MMP3MMP9 | |
| SCHEMBL7732168 | 0.80 | ADORA3 (0.37) | MAPTNPSR1MMP1MMP3MMP9 | |
| SCHEMBL7731071 | 0.79 | BCHE (0.45) | NPSR1MMP1MMP3MMP9CTSK | |
| SCHEMBL7731093 | 0.79 | MAPT (0.41) | MAPTNPSR1MMP1MMP3MMP9 | |
| SCHEMBL7730530 | 0.72 | MAPT (0.38) | MAPTNPSR1MMP1MMP3MMP9 | |
| SCHEMBL7723327 | 0.72 | MAPT (0.44) | MAPTNPSR1MMP1MMP3MMP9 | |
| SCHEMBL7730106 | 0.70 | CTSC (0.38) | CTSKCTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6436980-B1 | TRANSPORT PROTEIN SUPPRESSORS; MICROBIOCIDES | ESSENTIAL THERAPEUTICS, INC. | 2002-08-20 | — | — | US | disclosed |
| US-6204279-B1 | SECONDARY AMIDE CONTAINING BENZOXAZOLE DERIVATIVES | MICROCIDE PHARMACEUTICALS, INC. | 2001-03-20 | — | — | US | disclosed |