Hydrochloric Acid

Hydrochloric Acid

SCHEMBL7733737

CC1=C2C(=Nc3ccccc32)c2cc(C)cc([Zr+2]c3cc(C)cc4c3C(C)=C3C4=Nc4ccccc43)c21.[Cl-].[Cl-]

nearest known ligand 0.33

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Known targets — ChEMBL curated mechanism

ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA

The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
IDO1 P14902 1/20 0.33
GSK3A P49840 2/20 0.33
GSK3B P49841 2/20 0.33
CDK5 Q00535 2/20 0.33
CDK5R1 Q15078 2/20 0.33
FLT3 P36888 1/20 0.33
KDM4E B2RXH2 1/20 0.30
MEN1 O00255 1/20 0.30
APAF1 O14727 1/20 0.30
ALDH1A1 P00352 1/20 0.30
LMNA P02545 1/20 0.30
HSP90AA1 P07900 1/20 0.30
HSP90AB1 P08238 1/20 0.30
MAPT P10636 1/20 0.30
TSHR P16473 1/20 0.30
HK1 P19367 1/20 0.30
GALK1 P51570 1/20 0.30
KMT2A Q03164 1/20 0.30
HKDC1 Q2TB90 1/20 0.30
L3MBTL1 Q9Y468 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL7733742 0.79 GSK3A (0.33) IDO1GSK3AGSK3BCDK5CDK5R1
SCHEMBL4515365 0.58 IDO1 (0.54) IDO1GSK3AGSK3BCDK5CDK5R1
SCHEMBL12912867 0.58 IDO1 (0.50) IDO1GSK3AGSK3BCDK5CDK5R1
SCHEMBL7690744 0.57 ALDH1A1 (0.43) IDO1GSK3AGSK3BCDK5CDK5R1
SCHEMBL554572 0.57 IDO1 (0.35) IDO1GSK3AGSK3BCDK5CDK5R1
SCHEMBL12912968 0.56 MAPT (0.58) IDO1GSK3AGSK3BCDK5CDK5R1
SCHEMBL14455165 0.55 MAPK1 (0.44) IDO1KDM4EMEN1APAF1ALDH1A1
SCHEMBL30565769 0.55
SCHEMBL12912969 0.54 NPC1 (0.46) IDO1GSK3AGSK3BCDK5CDK5R1
SCHEMBL31106539 0.54 GSK3A (0.53) GSK3AGSK3BCDK5CDK5R1FLT3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6376629-B2 ORGANOMETALLIC COMPOUND EQUISTAR CHEMICALS, LP 2002-04-23 US disclosed
US-20010007848-A1 Single-site catalysts for olefin polymerization EQUISTAR CHEMICALS, L.P. 2001-07-12 US disclosed
US-6232260-B1 ORGANOMETALLIC COMPLEX COMPRISES A GROUP 3 TO 10 TRANSITION OR LANTHANIDE METAL, M, AND AT LEAST ONE INDENOINDOLYL LIGAND THAT IS .PI.-BONDED TO M. EQUISTAR CHEMICALS, L.P. 2001-05-15 US disclosed
WO-2001027125-A1 SINGLE-SITE CATALYSTS FOR OLEFIN POLYMERIZATION EQUISTAR CHEMICALS, L.P. (US) 2001-04-19 WO disclosed