SCHEMBL554572

SCHEMBL554572

Cc1c2c(c(C)c3c1=Nc1ccccc1-3)=Nc1ccccc1-2

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
IDO1 P14902 1/20 0.35
LMNA P02545 2/20 0.32
HSP90AA1 P07900 2/20 0.32
MAPT P10636 2/20 0.32
SMN1; SMN2 Q16637 2/20 0.32
HTT P42858 1/20 0.32
HIF1A Q16665 1/20 0.32
CYP1A2 P05177 1/20 0.31
CYP2D6 P10635 1/20 0.31
FLT3 P36888 1/20 0.31
GSK3A P49840 1/20 0.31
GSK3B P49841 1/20 0.31
CDK5 Q00535 1/20 0.31
CDK5R1 Q15078 1/20 0.31
MEN1 O00255 2/20 0.31
KMT2A Q03164 2/20 0.31
L3MBTL1 Q9Y468 2/20 0.31
KDM4E B2RXH2 1/20 0.31
APAF1 O14727 1/20 0.31
ALDH1A1 P00352 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL191346 0.70 IDO1 (0.40) IDO1LMNAHSP90AA1MAPTSMN1; SMN2
SCHEMBL30565769 0.70
SCHEMBL14455165 0.70 MAPK1 (0.44) IDO1LMNAHSP90AA1MAPTSMN1; SMN2
SCHEMBL29349590 0.70 IDO1 (0.40) IDO1LMNAHSP90AA1MAPTSMN1; SMN2
SCHEMBL18862390 0.69 ACHE (0.30) IDO1
SCHEMBL9959991 0.69 IDO1 (0.39) IDO1LMNAHSP90AA1MAPTSMN1; SMN2
SCHEMBL528427 0.68 IDO1 (0.32) IDO1LMNAHSP90AA1MAPTSMN1; SMN2
SCHEMBL18862222 0.66 IDO1 (0.34) IDO1CYP1A2CYP2D6
SCHEMBL14455164 0.65 MAPK1 (0.44) IDO1LMNAHSP90AA1MAPTSMN1; SMN2
SCHEMBL25431743 0.65 ALDH1A1 (0.36) IDO1LMNAHSP90AA1MAPTSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9184391-B2 Compound having indolocarbazole moiety and divalent linkage XEROX CORPORATION (US) 2015-11-10 US disclosed
US-20140148567-A1 COMPOUND HAVING INDOLOCARBAZOLE MOIETY AND DIVALENT LINKAGE XEROX CORPORATION (US) 2014-05-29 US disclosed
US-20140088313-A1 SUBSTITUTED INDOLOCARBAZOLES XEROX CORPORATION (US) 2014-03-27 US disclosed
US-8673959-B2 Polymer having indolocarbazole moiety and divalent linkage XEROX CORPORATION (US) 2014-03-18 US disclosed
US-8609867-B2 Substituted indolocarbazoles XEROX CORPORATION (US) 2013-12-17 US disclosed
EP-1671998-B1 Process to form compound with indolocarbazole moieties XEROX CORP (US) 2013-02-20 EP disclosed
US-20120157689-A1 SUBSTITUTED INDOLOCARBAZOLES XEROX CORPORATION (US) 2012-06-21 US disclosed
US-8110690-B2 Substituted indolocarbazoles XEROX CORPORATION (US) 2012-02-07 US disclosed
US-8003807-B2 organic thin film transistor with a semiconductor layer including the small molecule having didodecylindolo[3,2-b]carbazole groups XEROX CORPORATION (US) 2011-08-23 US disclosed
US-7868186-B2 Device containing polymer having indolocarbazole- repeat unit and divalent linkage XEROX CORPORATION (US) 2011-01-11 US disclosed
US-20070112167-A1 Device containing compound having indolocarbazole moiety and divalent linkage XEROX CORPORATION 2007-05-17 US disclosed
US-20070112172-A1 Compound having indolocarbazole moiety and divalent linkage XEROX CORPORATION 2007-05-17 US disclosed
US-7173140-B2 Process to form compound with indolocarbazole moieties XEROX CORPORATION (US) 2007-02-06 US disclosed
US-20060214155-A1 Compound with indolocarbazole moieties and devices containing such compound XEROX CORPORATION 2006-09-28 US disclosed
EP-1672713-A1 Compound with indolocarbazole moieties and electronic devices containing such compound Xerox Corporation (US) 2006-06-21 EP disclosed
EP-1671998-A2 Process to form compound with indolocarbazole moieties Xerox Corporation (US) 2006-06-21 EP disclosed
US-20060124923-A1 Thin film transistors including indolocarbazoles XEROX CORPORATION 2006-06-15 US disclosed
US-20060124921-A1 Compound with indolocarbazole moieties and devices containing such compound XEROX CORPORATION (US) 2006-06-15 US disclosed
US-20060125009-A1 Thin film transistors including indolocarbazoles XEROX CORPORATION 2006-06-15 US disclosed
US-20060128969-A1 Process to form compound with indolocarbazole moieties XEROX CORPORATION 2006-06-15 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070112172-A1 Compound having indolocarbazole moiety and divalent linkage INMT, IDO2, GRIN2C IDO1 7/4885LMNA 3087/4885HSP90AA1 3868/4885
US-20060128969-A1 Process to form compound with indolocarbazole moieties INMT, CYP3A4, PLK1 IDO1 4/4885LMNA 2632/4885HSP90AA1 2874/4885
US-20060214155-A1 Compound with indolocarbazole moieties and devices containing such compound BRD4, INO80C, BICRA IDO1 26/4885LMNA 3795/4885HSP90AA1 3986/4885
US-20060124921-A1 Compound with indolocarbazole moieties and devices containing such compound BRD4, INO80C, BICRA IDO1 26/4885LMNA 3795/4885HSP90AA1 3986/4885
US-20120157689-A1 SUBSTITUTED INDOLOCARBAZOLES HTR3C, HTR3A, AANAT IDO1 15/4885LMNA 3353/4885HSP90AA1 2623/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.