Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 2/20 | 0.33 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.32 |
| ▸ | GAA | P10253 | 4/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.32 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.32 |
| ▸ | SYK | P43405 | 1/20 | 0.32 |
| ▸ | AR | P10275 | 1/20 | 0.31 |
| ▸ | CYP46A1 | Q9Y6A2 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7734258 | 0.83 | TDO2 (0.35) | GRM2NTRK1PIK3CAPIK3CGCYP46A1 | |
| SCHEMBL6678474 | 0.81 | ALDH1A1 (0.39) | GRM2CYP1A2GAAALDH1A1KMT2A | |
| SCHEMBL7739635 | 0.80 | ALDH1A1 (0.37) | GRM2CYP1A2GAAALDH1A1KMT2A | |
| SCHEMBL6675178 | 0.80 | KDM4E (0.44) | KDM4EGAAALDH1A1KMT2AMAPT | |
| SCHEMBL6682248 | 0.80 | ALDH1A1 (0.40) | GRM2CYP1A2GAAALDH1A1KMT2A | |
| SCHEMBL6675695 | 0.79 | ALDH1A1 (0.39) | GRM2CYP1A2GAAALDH1A1KMT2A | |
| SCHEMBL6675941 | 0.79 | KDM4E (0.43) | KDM4ECYP1A2GAAALDH1A1KMT2A | |
| SCHEMBL7734178 | 0.79 | NTRK1 (0.35) | NTRK1PIK3CAPIK3CGKDM4ECYP1A2 | |
| SCHEMBL6681804 | 0.78 | GRM2 (0.38) | GRM2CYP1A2GAAALDH1A1KMT2A | |
| SCHEMBL6678436 | 0.78 | ALDH1A1 (0.40) | GAAALDH1A1KMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6414005-B1 | BRAIN DISORDERS; ALZHEIMER'S DISEASE; PARKINSON'S DISEASE | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2002-07-02 | — | — | US | disclosed |
| EP-1043312-A1 | HETEROCYCLIC COMPOUNDS HAVING NOS INHIBITORY ACTIVITIES | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2000-10-11 | — | — | EP | disclosed |