Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 2/20 | 0.35 |
| ▸ | AR | P10275 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | GAA | P10253 | 3/20 | 0.33 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.33 |
| ▸ | SYK | P43405 | 1/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.32 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.32 |
| ▸ | SCD | O00767 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7739634 | 0.79 | ALDH1A1 (0.38) | CYP1A2KDM4EALDH1A1GAAKMT2A | |
| SCHEMBL7734182 | 0.79 | GRM2 (0.33) | NTRK1ARCYP1A2KDM4EALDH1A1 | |
| SCHEMBL7740469 | 0.63 | HDAC6 (0.34) | CYP1A2PIK3CAPIK3CGSCDMAPKAPK2 | |
| SCHEMBL7740420 | 0.63 | SYK (0.37) | KDM4EALDH1A1GAASYKKMT2A | |
| SCHEMBL12071196 | 0.62 | CYP17A1 (0.51) | ALDH1A1GAAKMT2AMAPKAPK2 | |
| SCHEMBL27494826 | 0.62 | ALDH1A1 (0.41) | ALDH1A1GAAKMT2A | |
| SCHEMBL7740422 | 0.62 | SYK (0.40) | ALDH1A1GAASYKKMT2AMAPKAPK2 | |
| SCHEMBL7738859 | 0.62 | HDAC6 (0.36) | ARPIK3CAPIK3CGSCDMAPKAPK2 | |
| SCHEMBL7734258 | 0.62 | TDO2 (0.35) | NTRK1PIK3CAPIK3CG | |
| SCHEMBL6676211 | 0.61 | ALDH1A1 (0.58) | CYP1A2KDM4EALDH1A1GAAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6414005-B1 | BRAIN DISORDERS; ALZHEIMER'S DISEASE; PARKINSON'S DISEASE | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2002-07-02 | — | — | US | disclosed |
| EP-1043312-A1 | HETEROCYCLIC COMPOUNDS HAVING NOS INHIBITORY ACTIVITIES | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2000-10-11 | — | — | EP | disclosed |