Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 4/20 | 0.46 |
| ▸ | CYP2A6 | P11509 | 3/20 | 0.46 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.45 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.45 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.42 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.42 |
| ▸ | PLAU | P00749 | 2/20 | 0.42 |
| ▸ | PLG | P00747 | 1/20 | 0.42 |
| ▸ | PLAT | P00750 | 1/20 | 0.42 |
| ▸ | CYP11B2 | P19099 | 4/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | CYP17A1 | P05093 | 2/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.41 |
| ▸ | CYP1A1 | P04798 | 2/20 | 0.41 |
| ▸ | CYP2E1 | P05181 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9054823 | 0.89 | CYP1A2 (0.52) | CYP1A2CYP2A6HSD17B1HSD17B2GSTP1 | |
| SCHEMBL27822793 | 0.88 | DYRK1A (0.39) | CYP1A2CYP2A6DYRK1ACLK4NPC1 | |
| SCHEMBL27822808 | 0.88 | SMN1; SMN2 (0.41) | CYP1A2CYP2A6DYRK1ACLK4NPC1 | |
| SCHEMBL8734451 | 0.88 | GAPDH (0.53) | PLAUPLGPLATNPC1RAB9A | |
| SCHEMBL8732840 | 0.88 | GAPDH (0.53) | PLAUPLGPLATNPC1RAB9A | |
| SCHEMBL27802178 | 0.88 | CYP1A2 (0.46) | CYP1A2CYP2A6DYRK1ACLK4PLAU | |
| SCHEMBL7735652 | 0.85 | HSD17B1 (0.49) | CYP1A2CYP2A6HSD17B1HSD17B2GSTP1 | |
| SCHEMBL11723042 | 0.85 | CYP2A6 (0.52) | CYP1A2CYP2A6HSD17B1HSD17B2GSTP1 | |
| SCHEMBL8735796 | 0.81 | GAPDH (0.49) | NPC1RAB9ACYP3A4TDP1 | |
| SCHEMBL8734522 | 0.80 | HSD17B1 (0.41) | CYP1A2CYP2A6HSD17B1HSD17B2GSTP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0826680-B1 | Dihydronaphthalene and naphthalene compounds, intermediates, formulations, and methods of preparation thereof. | LILLY CO ELI (US) | 2001-10-24 | — | — | EP | disclosed |
| US-5958916-A | FOR INHIBITING BONE LOSS OR BONE RESORPTION | ELI LILLY AND COMPANY (US) | 1999-09-28 | — | — | US | disclosed |
| EP-0826680-A1 | Dihydronaphthalene and naphthalene compounds, intermediates, formulations, and methods | ELI LILLY AND COMPANY (US) | 1998-03-04 | — | — | EP | disclosed |
| EP-0826670-A1 | Naphthalene compounds, intermediates, formulations, and methods | ELI LILLY AND COMPANY (US) | 1998-03-04 | — | — | EP | disclosed |