Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.46 |
| ▸ | DRD1 | P21728 | 2/20 | 0.46 |
| ▸ | DRD5 | P21918 | 2/20 | 0.46 |
| ▸ | HTR2A | P28223 | 2/20 | 0.37 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.36 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.36 |
| ▸ | HTR2C | P28335 | 2/20 | 0.36 |
| ▸ | HTR6 | P50406 | 1/20 | 0.36 |
| ▸ | DRD4 | P21917 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | BCHE | P06276 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7735728 | 0.77 | MTNR1A (0.54) | MTNR1AMTNR1B | |
| SCHEMBL7741773 | 0.75 | MTNR1A (0.65) | HTR2AMTNR1AMTNR1BHTR2CHTR2B | |
| SCHEMBL7379841 | 0.73 | HTR6 (0.56) | HTR2AMTNR1AMTNR1BHTR6BCHE | |
| SCHEMBL29655195 | 0.73 | HTR6 (0.56) | HTR2AMTNR1AMTNR1BHTR6BCHE | |
| SCHEMBL9643992 | 0.69 | DRD2 (0.46) | DRD2DRD1DRD5HTR2AHTR2C | |
| SCHEMBL18440732 | 0.65 | CYP19A1 (0.55) | HTR2A | |
| SCHEMBL7410004 | 0.65 | ESR1 (0.62) | DRD2HTR2AMTNR1AMTNR1BHTR6 | |
| SCHEMBL11260060 | 0.64 | HTR2A (0.42) | DRD2DRD1DRD5HTR2AHTR2C | |
| SCHEMBL7740360 | 0.63 | MTNR1A (0.67) | HTR2AMTNR1AMTNR1BHTR2CHTR2B | |
| SCHEMBL9642903 | 0.63 | GAA (0.39) | HTR2AMTNR1AMTNR1BHTR2CHTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6423870-B1 | ANTICOAGULANTS; CIRCADIAN RHYTHM DISORDERS; SLEEP DISORDERS | LES LABORATOIRES SERVIER (FR) | 2002-07-23 | — | — | US | disclosed |