Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.64 |
| ▸ | PKM | P14618 | 1/20 | 0.64 |
| ▸ | PPARG | P37231 | 1/20 | 0.64 |
| ▸ | HTT | P42858 | 1/20 | 0.64 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.64 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.64 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.64 |
| ▸ | HIF1A | Q16665 | 10/20 | 0.62 |
| ▸ | PGR | P06401 | 4/20 | 0.62 |
| ▸ | AR | P10275 | 3/20 | 0.62 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.62 |
| ▸ | LMNA | P02545 | 2/20 | 0.62 |
| ▸ | SERPINA6 | P08185 | 1/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.60 |
| ▸ | NR3C1 | P04150 | 3/20 | 0.60 |
| ▸ | NR3C2 | P08235 | 2/20 | 0.60 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.60 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.60 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7741842 | 0.96 | HIF1A (0.60) | ALDH1A1PKMPPARGHTTNCOA2 | |
| SCHEMBL2016044 | 0.90 | NR3C1 (0.73) | HIF1APGRARCHRM1LMNA | |
| SCHEMBL2020336 | 0.89 | HIF1A (0.62) | ALDH1A1PKMPPARGHTTNCOA2 | |
| SCHEMBL2017765 | 0.89 | NR3C1 (0.57) | ALDH1A1PKMPPARGHTTNCOA2 | |
| SCHEMBL8500154 | 0.87 | CYP3A4 (0.60) | ALDH1A1PKMPPARGHTTNCOA2 | |
| SCHEMBL9199016 | 0.87 | HIF1A (0.55) | ALDH1A1PKMPPARGHTTNCOA2 | |
| SCHEMBL7735905 | 0.86 | HIF1A (0.66) | HIF1APGRARCHRM1LMNA | |
| SCHEMBL7751385 | 0.85 | ALDH1A1 (0.84) | ALDH1A1PKMPPARGHTTNCOA2 | |
| SCHEMBL7735898 | 0.85 | ALDH1A1 (0.84) | ALDH1A1PKMPPARGHTTNCOA2 | |
| SCHEMBL17151413 | 0.85 | ALDH1A1 (0.84) | ALDH1A1PKMPPARGHTTNCOA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6423340-B1 | GASTROINTESTINAL DISORDERS, CROHN'S COLITIS | AKTIEBOLAGET DRACO (SE) | 2002-07-23 | — | — | US | disclosed |
| US-5643602-A | TIME RELEASE PELLETS FOR INTESTINES | ASTRA AKTIEBOLAG (SE) | 1997-07-01 | — | — | US | disclosed |
| US-4695625-A | Process for the preparation of 16,17 acetals of pregnane derivatives | SICOR SOCIETA ITALIANA CORTICOSTEROIDI S.P.A. (IT) | 1987-09-22 | — | — | US | disclosed |
| EP-0164636-A2 | A process for the preparation of 16,17 acetals of pregnane derivatives and compounds obtained therefrom | SICOR Società Italiana Corticosteroidi S.p.A. (IT) | 1985-12-18 | — | — | EP | disclosed |
| EP-0054010-B1 | 4-PREGNENE-DERIVATIVES, A PROCESS FOR THEIR PREPARATION AND COMPOSITION FOR THE TREATMENT OF INFLAMMATORY CONDITIONS | Aktiebolaget Draco (SE) | 1985-02-20 | — | — | EP | disclosed |
| US-4404200-A | 16, 17-ACETALS OF 16-ALPHA-HYDROXYCORTISOL | AKTIEBOLAGET DRACO (SE) | 1983-09-13 | — | — | US | disclosed |
| EP-0054010-A1 | 4-Pregnene-derivatives, a process for their preparation and composition for the treatment of inflammatory conditions | Aktiebolaget Draco (SE) | 1982-06-16 | — | — | EP | disclosed |