Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.61 |
| ▸ | HPGD | P15428 | 2/20 | 0.61 |
| ▸ | NPC1 | O15118 | 2/20 | 0.61 |
| ▸ | USP2 | O75604 | 1/20 | 0.61 |
| ▸ | RAD52 | P43351 | 2/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | DRD4 | P21917 | 4/20 | 0.48 |
| ▸ | DRD2 | P14416 | 3/20 | 0.48 |
| ▸ | DRD3 | P35462 | 3/20 | 0.48 |
| ▸ | RORC | P51449 | 1/20 | 0.47 |
| ▸ | MITF | O75030 | 1/20 | 0.47 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.47 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12460039 | 0.84 | RAD52 (0.47) | ALDH1A1NPC1RAD52NPSR1KDM4E | |
| SCHEMBL7735984 | 0.82 | ALDH1A1 (0.67) | ALDH1A1HPGDNPC1USP2RAD52 | |
| SCHEMBL7738147 | 0.81 | ALDH1A1 (0.81) | ALDH1A1HPGDNPC1USP2RAD52 | |
| SCHEMBL7726499 | 0.80 | ACHE (0.50) | ALDH1A1HPGDNPC1MEN1KMT2A | |
| SCHEMBL7735766 | 0.79 | SMN1; SMN2 (0.64) | ALDH1A1HPGDNPC1USP2RAD52 | |
| SCHEMBL31703375 | 0.78 | HPGD (0.53) | ALDH1A1HPGDUSP2NPSR1MEN1 | |
| SCHEMBL7738167 | 0.76 | ALDH1A1 (1.00) | ALDH1A1HPGDNPC1USP2MAPK1 | |
| SCHEMBL6243365 | 0.75 | ALDH1A1 (0.66) | ALDH1A1NPC1USP2DRD4DRD2 | |
| SCHEMBL3305614 | 0.75 | ALDH1A1 (0.61) | ALDH1A1HPGDNPC1USP2RAD52 | |
| SCHEMBL1181160 | 0.74 | ALDH1A1 (0.59) | ALDH1A1HPGDNPC1USP2RAD52 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6410792-B1 | OBESITY DISEASES | BAYER CORPORATION | 2002-06-25 | — | — | US | disclosed |
| US-6048900-A | FOR TREATING EATING DISORDERS, INSULIN RESISTANT DIABETES, HYPERTENSION, HYPERLIPEMIA | BAYER CORPORATION (US) | 2000-04-11 | — | — | US | disclosed |