Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.81 |
| ▸ | NPC1 | O15118 | 4/20 | 0.81 |
| ▸ | HPGD | P15428 | 2/20 | 0.81 |
| ▸ | USP2 | O75604 | 2/20 | 0.81 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.62 |
| ▸ | THRB | P10828 | 1/20 | 0.62 |
| ▸ | HTT | P42858 | 1/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.61 |
| ▸ | MEN1 | O00255 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.61 |
| ▸ | TP53 | P04637 | 1/20 | 0.59 |
| ▸ | RAB9A | P51151 | 1/20 | 0.59 |
| ▸ | POLB | P06746 | 2/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 1/20 | 0.59 |
| ▸ | RAD52 | P43351 | 1/20 | 0.59 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.58 |
| ▸ | MITF | O75030 | 1/20 | 0.58 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7738167 | 0.89 | ALDH1A1 (1.00) | ALDH1A1NPC1HPGDUSP2HRH3 | |
| SCHEMBL7735984 | 0.85 | ALDH1A1 (0.67) | ALDH1A1NPC1HPGDUSP2KDM4E | |
| SCHEMBL7735928 | 0.85 | ALDH1A1 (0.71) | ALDH1A1NPC1HPGDUSP2KDM4E | |
| SCHEMBL7735766 | 0.82 | SMN1; SMN2 (0.64) | ALDH1A1NPC1HPGDUSP2KDM4E | |
| SCHEMBL8155606 | 0.81 | SMN1; SMN2 (0.81) | ALDH1A1NPC1HPGDUSP2KDM4E | |
| SCHEMBL7736314 | 0.81 | ALDH1A1 (0.62) | ALDH1A1NPC1HPGDUSP2KDM4E | |
| SCHEMBL7736310 | 0.81 | ALDH1A1 (0.61) | ALDH1A1NPC1HPGDUSP2KDM4E | |
| SCHEMBL3305614 | 0.81 | ALDH1A1 (0.61) | ALDH1A1NPC1HPGDUSP2KDM4E | |
| SCHEMBL7726594 | 0.81 | ALDH1A1 (0.61) | ALDH1A1NPC1HPGDUSP2KDM4E | |
| SCHEMBL14537720 | 0.80 | TSHR (0.75) | ALDH1A1NPC1HPGDUSP2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6410792-B1 | OBESITY DISEASES | BAYER CORPORATION | 2002-06-25 | — | — | US | disclosed |
| US-6048900-A | FOR TREATING EATING DISORDERS, INSULIN RESISTANT DIABETES, HYPERTENSION, HYPERLIPEMIA | BAYER CORPORATION (US) | 2000-04-11 | — | — | US | disclosed |
| EP-0910565-A1 | AMIDE DERIVATIVES AS SELECTIVE NEUROPEPTIDE Y RECEPTOR ANTAGONISTS | Bayer Corporation (US) | 1999-04-28 | — | — | EP | disclosed |
| WO-1998035957-A1 | AMIDE DERIVATIVES AS SELECTIVE NEUROPEPTIDE Y RECEPTOR ANTAGONISTS | BAYER CORPORATION (US) | 1998-08-20 | — | — | WO | disclosed |