Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 4/20 | 0.46 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.44 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.44 |
| ▸ | HTR6 | P50406 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | DRD3 | P35462 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7732078 | 0.84 | DRD2 (0.50) | HTR1AADRA1DADRA1AADRA1BDRD2 | |
| SCHEMBL6474943 | 0.82 | HTR1A (0.59) | HTR1AADRA1DADRA1AADRA1BDRD2 | |
| SCHEMBL7736595 | 0.81 | ALDH1A1 (0.40) | HTR1ALMNAMAPTHPGDMAPK1 | |
| SCHEMBL8129784 | 0.76 | DRD2 (0.59) | HTR1AADRA1DADRA1AADRA1BHTR6 | |
| SCHEMBL7607942 | 0.73 | HTR1A (0.58) | HTR1AADRA1DADRA1AADRA1BDRD2 | |
| SCHEMBL6936848 | 0.71 | HTR1A (0.67) | HTR1AADRA1DADRA1AADRA1BDRD2 | |
| SCHEMBL21669399 | 0.71 | SERPINE1 (0.57) | HTR1AADRA1AHTR6DRD2DRD3 | |
| SCHEMBL16690122 | 0.69 | KAT2B (0.56) | DRD3LMNAMAPTALDH1A1HTT | |
| SCHEMBL6934206 | 0.69 | HTR1A (0.67) | HTR1AADRA1DADRA1AADRA1BDRD2 | |
| SCHEMBL6930794 | 0.69 | DRD2 (0.66) | HTR1AADRA1DADRA1AADRA1BHTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6399614-B1 | TREATING NEUROMUSCULAR DYSFUNCTION OF LOWER URINARY TRACT VIA PERIPHERAL OR CENTRAL NERVOUS SYSTEM; SEROTONIN RECEPTOR ANTAGONIST | RECORDATI S.A. CHEMICAL AND PHARMACEUTICAL COMPANY (CH) | 2002-06-04 | — | — | US | disclosed |