Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.43 |
| ▸ | BAD | Q92934 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | HTR2B | P41595 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 4/20 | 0.37 |
| ▸ | HTR1A | P08908 | 3/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.37 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.37 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.36 |
| ▸ | DRD1 | P21728 | 1/20 | 0.36 |
| ▸ | DRD5 | P21918 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8493200 | 0.89 | MEN1 (0.42) | DRD2HTR1ADRD1DRD5DRD3 | |
| SCHEMBL8497315 | 0.79 | ALDH1A1 (0.40) | DRD2HTR1AADRA1BDRD1DRD5 | |
| SCHEMBL4703874 | 0.79 | NPC1 (0.41) | BCL2L1BADHTR2CHTR2BHRH3 | |
| SCHEMBL14202152 | 0.78 | KDM4E (0.55) | CHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL22129196 | 0.78 | HRH3 (0.51) | BCL2L1BADHRH3DRD2HTR1A | |
| SCHEMBL2743854 | 0.75 | ADRA1B (0.42) | BCL2L1BADHTR2CHTR2BHRH3 | |
| SCHEMBL7737082 | 0.74 | HRH3 (0.46) | HRH3HDAC1HDAC6 | |
| SCHEMBL15787244 | 0.74 | DRD2 (0.47) | DRD2HTR1ADRD1 | |
| SCHEMBL4701898 | 0.72 | NOTUM (0.44) | HRH3CHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL13911374 | 0.71 | BCL2L1 (0.46) | BCL2L1BADDRD2DRD1DRD5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6407096-B1 | 1,4-BENZOTHIAZINE AND 1,4-BENZOXAZINE DERIVATIVES; HYPOTENSIVE, ANTIISCHEMIC, ANTIALLERGEN, ANTIASTHMATIC AND ANTICOAGULANT AGENTS; CARDIOVASCULAR DISORDERS | TORAY INDUSTRIES, INC. (JP) | 2002-06-18 | — | — | US | disclosed |
| EP-1028113-A1 | FUSED BENZENE HETEROCYCLE DERIVATIVES AND UTILIZATION THEREOF | TORAY INDUSTRIES, INC. (JP) | 2000-08-16 | — | — | EP | disclosed |