Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR2 | Q92731 | 6/20 | 0.43 |
| ▸ | ESR1 | P03372 | 5/20 | 0.43 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.40 |
| ▸ | ABHD6 | Q9BV23 | 4/20 | 0.38 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.37 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.36 |
| ▸ | CCR2 | P41597 | 1/20 | 0.35 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.34 |
| ▸ | PNMT | P11086 | 3/20 | 0.33 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.33 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.33 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7738243 | 0.84 | ABHD6 (0.54) | ESR2ESR1AKR1C3ABHD6NR1H2 | |
| SCHEMBL7745997 | 0.84 | NR1H2 (0.54) | ESR2ESR1ABHD6NR1H2PKM | |
| SCHEMBL7738183 | 0.80 | DRD2 (0.45) | ESR2ESR1AKR1C3DPP7PNMT | |
| SCHEMBL2616863 | 0.76 | ESR1 (0.72) | ESR2ESR1AKR1C3ABHD6NR1H2 | |
| SCHEMBL566629 | 0.73 | ESR1 (0.58) | ESR2ESR1AKR1C3ABHD6AKR1C1 | |
| SCHEMBL1365173 | 0.70 | NR1H2 (0.72) | ESR2ESR1ABHD6NR1H2DPP7 | |
| SCHEMBL3909239 | 0.68 | NOTUM (0.63) | ESR2ESR1AKR1C3NR1H2AKR1C1 | |
| SCHEMBL8591886 | 0.67 | ESR2 (0.57) | ESR2ESR1ABHD6NR1H2 | |
| SCHEMBL4139993 | 0.66 | CA12 (0.63) | ESR2ESR1ABHD6 | |
| SCHEMBL8308725 | 0.66 | NR1H2 (0.65) | ESR2ESR1NR1H2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1045843-A4 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 2001-10-24 | — | — | EP | disclosed |
| EP-1045843-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 2000-10-25 | — | — | EP | disclosed |
| US-5977134-A | Inhibitors of farnesyl-protein transferase | MERCK & CO., INC. (US) | 1999-11-02 | — | — | US | disclosed |
| WO-1999028313-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1999-06-10 | — | — | WO | disclosed |