Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.37 |
| ▸ | HPGD | P15428 | 4/20 | 0.37 |
| ▸ | GLA | P06280 | 4/20 | 0.37 |
| ▸ | GAA | P10253 | 4/20 | 0.37 |
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 5/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.37 |
| ▸ | TYMP | P19971 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | GCK | P35557 | 1/20 | 0.34 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.33 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7740612 | 0.85 | PRKAG1 (0.40) | ALDH1A1HPGDMEN1KMT2AATM | |
| SCHEMBL7741254 | 0.83 | PTGES (0.37) | KDM4EALDH1A1HPGDGLAGAA | |
| SCHEMBL7739842 | 0.83 | PRKAG1 (0.42) | ALDH1A1HPGDMEN1KMT2AGCK | |
| SCHEMBL7739968 | 0.81 | GRIN2D (0.34) | MAPTMEN1KMT2ATYMPSMN1; SMN2 | |
| SCHEMBL7741117 | 0.80 | PRKAG1 (0.37) | KDM4EALDH1A1HPGDGLAGAA | |
| SCHEMBL7739643 | 0.79 | GSK3B (0.37) | KDM4EALDH1A1HPGDGAANPSR1 | |
| SCHEMBL7734964 | 0.77 | ALDH1A1 (0.41) | ALDH1A1GAAMAPTNPSR1HTT | |
| SCHEMBL7742681 | 0.77 | CDK5 (0.35) | MAPTMEN1KMT2AGCKGRIN2D | |
| SCHEMBL7741113 | 0.76 | IDH1 (0.41) | KDM4EALDH1A1GRIN2DGRIN3BGRIN1 | |
| SCHEMBL7740617 | 0.76 | PTGES (0.36) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6420386-B1 | SPINAL TRAUMATISM, EPILEPSY, CHRONIC NEURODEGENERATIVE DISEASES SUCH AS ALZHEIMER'S DISEASE, SCHIZOPHRENIA, LATERAL AMYOTROPHIC SCLEROSIS OR HUNTINGTON'S CHOREA. | LES LABORATORIES SERVIER (FR) | 2002-07-16 | — | — | US | disclosed |